Verticil Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Terbinafine HCl
Used For
Fungal Infection
How it works
Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations Terbinafine tablets is fungicidal against dermatophytes, moulds and certain dimorphic fungi. The activity versus yeasts is fungicidal or fungistatic depending on the species. Terbinafine tablets interfere selectively with fungal sterol biosynthesis at an early stage through inhibition of the enzyme squalene epoxidase. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene in the fungal cell membrane. Both the deficiency in ergosterol and the accumulation of squalene are responsible for fungal cell death.
Verticil Tablets Usage And Safety
Dosage
Terbinafine HCl
Side Effects
Very common (may affect more than 1 in 10 people) • Stomach problems such as loss of appetite, ache, indigestion, feeling bloated or sick • Diarrhoea • Itching, rash or swelling • Pains in the muscles and joints Common (may affect up to 1 in 10 people) • Headache Uncommon (may affect up to 1 in 100 people) • Taste loss and taste disturbance. This usually disappears within several weeks after you stop taking the medicine. However, a very small number of people, (less than 1 in 10,000), have reported that the taste disturbance lasts for some time and, as a result, they go off their food and lose weight.There have also been reports of some people experiencing anxiety or symptoms of depression as a result of these taste disturbances.
Drug Interactions
• Rifampicin (an antibiotic). • Cimetidine (used to treat stomach ulcers). • Antidepressants including tricyclic antidepressants, SSRIs (selective serotonin reuptake inhibitors) or MAOIs (monoamine oxidase inhibitors) (medicines for depression). • Oral contraceptives (as irregular periods and breakthrough bleeding may occur in some female patients). • Beta blockers or antiarrhythmics (for heart problems). • Warfarin, a medicine used to thin your blood. • Medicines to treat heart problems (eg propafenone, amiodarone). • Ciclosporin (a medicine used to control your body’s immune system in order to prevent rejection of transplanted organs). • Medicines used to treat fungal infections (e.g. fluconazole, ketoconazole) • Medicines used to treat cough (e.g. dextromethorphan) • Caffeine
Indication
Terbinafine is used for the treatment of fungal infections of: • The groin area. • The skin (ring worm). • Toe and finger nails (yellow, opaque and thickened nails). • The feet (athlete’s foot).
When not to Use
Do not take Terbinafine if you: • Are allergic to terbinafine or any of the other ingredients of this medicine . • Have or have had any liver problems. • Are breast-feeding.
Verticil Tablets Precautions
Precaution
Terbinafine should be used with caution in patients with lupus erythematosus as very rare cases of lupus erythematosus have been reported.
Verticil Tablets Warnings
Warning 1
Terbinafine is contraindicated for patients with chronic or active hepatic disease. Before prescribing Terbinafine , a liver function test should be performed and any pre-existing liver disease should be assessed.
Warning 2
Serious skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms) have been very rarely reported in patients taking Terbinafine . If progressive skin rash occurs, Terbinafine treatment should be discontinued.
Warning 3
Very rare cases of blood dyscrasias (neutropenia, agranulocytosis, thrombocytopenia, pancytopenia) have been reported in patients treated with Terbinafine tablets. Aetiology of any blood dyscrasias that occur in patients treated with Terbinafine tablets should be evaluated and consideration should be given for a possible change in medication regimen, including discontinuation of treatment with Terbinafine .
Verticil Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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