Tryptanol Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Amitriptyline HCl
Used For
Depression
How it works
Amitriptyline is a tricyclic antidepressant and an analgesic. It has marked anticholinergic and sedative properties. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity. The mechanism of action also includes ion-channel blocking effects on sodium, potassium and NMDA channel at both central and spinal cord level. The noradrenaline, sodium and the NMDA effects are mechanisms known to be involved in the maintenance of neuropathic pain, chronic tension type headache prophylaxis and migraine prophylaxis. The pain-reducing effect of amitriptyline is not linked to its anti-depressive properties.
Tryptanol Tablets Usage And Safety
Dosage
Amitriptyline HCl
Side Effects
Very common (may affect more than 1 in 10 people): • Sleepiness/drowsiness • Shakiness of hands or other body parts • Dizziness, headache, dizziness when you stand up due to low blood pressure (orthostatic hypotension) • Irregular, hard, or rapid heartbeat • Dry mouth, constipation, nausea • Excessive sweating • Weight gain • Slurred or slow speech • Aggression • Congested nose. Common: (may affect up to 1 in 10 people): • Confusion • sexual disturbances (decreased sex-drive, problems with erection) • disturbance in attention • changes in taste • numbness or tingling in the arms or legs • disturbed coordination • dilated pupils • heart block • fatigue • low sodium concentration in the blood • agitation • urination disorders • feeling thirsty. Uncommon (may affect up to 1 in 100 people): • Excitement, anxiety, difficulties sleeping, nightmares • convulsions • tinnitus • increased blood pressure • diarrhoea, vomiting • skin rash, nettle rash (urticaria), swelling of the face and tongue.
Drug Interactions
Monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline , adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine , calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine, reserpine and methyldopa , atropine, hyoscyamine , thioridazine , nefopam, tramadol and morphine , buprenorphine , fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole) , sedatives (e.g. barbiturates) , antidepressants (e.g. SSRIs (fluoxetine, paroxetine, fluvoxamine), and bupropion) , medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics) , cimetidine (used to treat stomach ulcers) , methylphenidate (used to treat ADHD) , ritonavir (used to treat HIV) .
Indication
This medicine is used to treat: • Depression in adults (major depressive episodes) • Neuropathic pain in adults • Chronic tension type headache prophylaxis in adults • Migraine prophylaxis in adults .
When not to Use
Do not take Amitriptyline if you or your child (if they are the patient): • Are allergic to amitriptyline or any of the other ingredients of this medicine .• Recently have had a heart attack (myocardial infarction) • Have heart problems such as disturbances in heart rhythm which are seen on an electrocardiogram (ECG), heart block, or coronary artery disease • Are taking medicines known as monoamine oxidase inhibitors (MAOIs) .
Tryptanol Tablets Precautions
Precaution
Some patients with manic-depressive illness may enter into a manic phase. This is characterised by profuse and rapidly changing ideas, exaggerated gaiety and excessive physical activity. In such cases, it is important to contact your doctor who probably will change your medication.
Tryptanol Tablets Warnings
Warning 1
Heart rhythm disorders and hypotension may occur if you receive a high dosage of amitriptyline. This might also occur in usual doses if you have pre-existing heart disease.
Warning 2
The use of Buprenorphine together with Amitriptyline can lead to serotonin syndrome, a potentially life threatening condition .
Warning 3
If you are depressed, you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer .
Tryptanol Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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