Teph Insta 40 Capsules 40Mg (1 Strip = 7 Capsules)

Requires Prescription: Yes

Generics: Omeprazole + Sodium Bicarbonate

Used For: Gastroesophageal Reflux Disease (GERD)

How It Works:

Omeprazole, a proton pump inhibitor, reduces gastric acid secretion by irreversibly blocking the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, which is the proton pump of the gastric parietal cells. This action inhibits both basal and stimulated acid secretion, regardless of the stimulus. Sodium bicarbonate helps neutralize stomach acid and enhances the effectiveness of omeprazole.

Teph Insta Usage and Safety:

Dosage:

Omeprazole + Sodium Bicarbonate

Side Effects:

Common:

Central and Peripheral Nervous System: Headache

Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence

Uncommon:

Central and Peripheral Nervous System: Dizziness, paresthesia, somnolence, insomnia, vertigo

Hepatic: Increased liver enzymes

Skin: Rash, pruritus, urticaria

Other: Malaise

Rare:

Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (primarily in severely ill patients)

Endocrine: Gynecomastia

Drug Interactions:

Ketoconazole, itraconazole

Diazepam, citalopram, imipramine, clomipramine

Phenytoin

Atazanavir

Digoxin

Clopidogrel

Posaconazole

Erlotinib, saquinavir

Tacrolimus

Methotrexate

Clarithromycin

CYP2C19 or CYP3A4 inducers (e.g., rifampicin, St. John’s Wort) and inhibitors (e.g., voriconazole)

Indication:

Omeprazole is indicated in adults for:

Treatment of erosive reflux esophagitis

Long-term management to prevent relapse in patients with healed esophagitis

Symptomatic treatment of gastroesophageal reflux disease (GERD)

When Not to Use:

Omeprazole is contraindicated in:

Patients with known hypersensitivity to any component of the formulation or substituted benzimidazoles

Patients taking nelfinavir

Teph Insta Precautions:

Precaution:

A symptomatic response to therapy with omeprazole does not rule out the possibility of gastric malignancy.

Teph Insta Warnings:

Warning 1:

Long-term use of omeprazole may be associated with atrophic gastritis, as noted in gastric corpus biopsies.

Warning 2:

Sodium bicarbonate should be used with caution in patients with Bartter’s syndrome, hypokalemia, respiratory alkalosis, and issues with acid-base balance. Long-term use with calcium or milk may cause milk-alkali syndrome.

Warning 3:

Omeprazole powder for oral suspension contains sodium in the form of sodium bicarbonate, which should be considered for patients on a sodium-restricted diet.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medication.

Storage:

Store at room temperature, away from direct light and heat.