Requires Prescription: Yes

Generics: Vonoprazan

Used For: Acidity & Ulcers

How It Works:

Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits the H+, K+-ATPase enzyme in a reversible and potassium-competitive manner. Unlike traditional proton pump inhibitors, it does not require activation by acid. It binds to the acid production site on gastric parietal cells, providing long-lasting inhibition of gastric acid production. This mechanism helps prevent mucosal damage in the upper gastrointestinal tract.

Scivono Tablets Usage and Safety:

Dosage:

Vonoprazan

Side Effects:

Common: Diarrhea, constipation, nausea, abdominal distension

Less Common: Drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash

Laboratory Abnormalities: Increased gamma-glutamyl transferase, AST, ALT, ALP, LDH, and eosinophilia

Other: Edema

Drug Interactions:

CYP3A4 inhibitors: Clarithromycin, Itraconazole

Digoxin, Methyldigoxin

Tyrosine kinase inhibitors: Gefitinib, Nilotinib, Erlotinib

Indication:

Vonoprazan is indicated for:

Gastric ulcer

Duodenal ulcer

Reflux esophagitis

Prevention of recurrence of gastric or duodenal ulcers during low-dose aspirin or NSAID administration

When Not to Use:

Vonoprazan is contraindicated in:

Patients with hypersensitivity to Vonoprazan or any excipient of the product

Patients receiving atazanavir sulfate, nelfinavir, or rilpivirine hydrochloride

Scivono Tablets Precautions:

Precaution:

Monitor the course of the disease closely during treatment. Use the minimum effective dose necessary based on the condition of the disease.

Scivono Tablets Warnings:

Warning 1:

For maintaining healing of reflux esophagitis, Vonoprazan should only be used in patients with recurrent or persistent symptoms. Avoid use in patients who do not need maintenance therapy.

Warning 2:

If healing is maintained over a long period and there is no risk of recurrence, consider reducing the dose from 20 mg to 10 mg or discontinuing the medication.

Warning 3:

Use Vonoprazan with caution in patients with renal disorders, as delayed excretion may increase blood concentration of the drug.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medicine.

Storage:

Store at room temperature, away from direct light and heat