Requires Prescription: Yes
Generics: Omeprazole
Used For: Gastroesophageal Reflux Disease (GERD)
How It Works:
Omeprazole works by inhibiting the secretion of gastric acid through an irreversible blockade of the enzyme system hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), also known as the proton pump, located in the gastric parietal cells. This mechanism results in a dose-dependent reduction of both basal and stimulated acid secretion, regardless of the stimulus.
Sante Capsules Usage and Safety:
Dosage:
Omeprazole
Side Effects:
Common:
Central and Peripheral Nervous System: Headache
Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence
Uncommon:
Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo
Hepatic: Increased liver enzymes
Skin: Rash, pruritis, urticaria
Other: Malaise
Rare:
Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (more common in severely ill patients)
Endocrine: Gynecomastia
Drug Interactions:
Ketoconazole, itraconazole
Diazepam, citalopram, imipramine, clomipramine
Phenytoin
Atazanavir
Digoxin, clopidogrel
Posaconazole, erlotinib, saquinavir
Tacrolimus, methotrexate
Clarithromycin
CYP2C19 or CYP3A4 inhibitors/inducers (e.g., rifampicin, St. John’s Wort)
Indication:
Treatment of erosive reflux esophagitis
Long-term management of healed esophagitis to prevent relapse
Symptomatic treatment of gastroesophageal reflux disease (GERD)
When Not to Use:
Contraindicated in patients with hypersensitivity to any component of the formulation or substituted benzimidazoles
Must not be used with nelfinavir
Sante Capsules Precautions:
Precaution:
Omeprazole, like other acid-blocking medications, may impair vitamin B12 (cyanocobalamin) absorption due to reduced gastric acid levels. This is important to consider in patients with low body stores or those at risk of impaired vitamin B12 absorption during long-term therapy.
Sante Capsules Warnings:
Warning 1:
When a gastric ulcer is suspected, it is important to rule out malignancy, as omeprazole may relieve symptoms and potentially delay diagnosis.
Warning 2:
High doses or prolonged use of proton pump inhibitors (more than one year) may slightly increase the risk of hip, wrist, and spine fractures, particularly in the elderly or those with other risk factors.
Warning 3:
Dose adjustments may be necessary for patients with impaired hepatic function, as omeprazole’s bioavailability and half-life may be increased.
Additional Information:
Pregnancy Category:
Always consult your physician before using any medication.
Storage:
Store at room temperature, away from direct light and heat.
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