Risek Insta Sugar Free Sachets 40Mg (1 Box = 10 Sachets)

Requires Prescription: Yes

Generics: Omeprazole + Sodium Bicarbonate

Used For: Gastroesophageal Reflux Disease (GERD)

How It Works:

Omeprazole is a substituted benzimidazole that reduces gastric acid secretion through a unique mechanism. It inhibits the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), also known as the proton pump, in gastric parietal cells. This irreversible blockade suppresses both basal and stimulated acid secretion, regardless of the stimulus. Sodium bicarbonate acts as a buffering agent to neutralize excess stomach acid.

Risek Insta Usage and Safety:

Dosage:

Omeprazole + Sodium Bicarbonate

Side Effects:

Common:

Central and Peripheral Nervous System: Headache

Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence

Uncommon:

Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo

Hepatic: Increased liver enzymes

Skin: Rash, pruritis, urticaria

Other: Malaise

Rare:

Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (mainly in severely ill patients)

Endocrine: Gynecomastia

Drug Interactions:

Ketoconazole, itraconazole

Diazepam, citalopram, imipramine, clomipramine

Phenytoin

Atazanavir

Digoxin, clopidogrel

Posaconazole, erlotinib, saquinavir

Tacrolimus, methotrexate

Clarithromycin

CYP2C19 or CYP3A4 inhibitors/inducers (e.g., rifampicin, St. John’s Wort)

Indication:

Treatment of erosive reflux esophagitis

Long-term management of patients with healed esophagitis to prevent relapse

Symptomatic treatment of gastroesophageal reflux disease (GERD)

When Not to Use:

Contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles

Must not be used with nelfinavir

Risek Insta Precautions:

Precaution:

A symptomatic response to omeprazole does not exclude the possibility of gastric malignancy.

Risek Insta Warnings:

Warning 1:

Atrophic gastritis has been observed in gastric corpus biopsies from patients on long-term omeprazole therapy.

Warning 2:

Sodium bicarbonate should be used with caution in patients with Bartter’s syndrome, hypokalemia, respiratory alkalosis, or acid-base balance issues. Long-term use with calcium or milk may cause milk-alkali syndrome.

Warning 3:

Omeprazole powder for oral suspension contains sodium in the form of sodium bicarbonate, which should be considered for patients on a sodium-restricted diet.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medicine.

Storage:

Store at room temperature, away from direct light and heat.