Requires Prescription: Yes
Generics: Omeprazole
Used For: Gastroesophageal Reflux Disease (GERD)
How It Works: Omeprazole inhibits gastric acid secretion by irreversibly blocking the H+/K+ ATPase enzyme system, also known as the proton pump, in the gastric parietal cells. This effect is dose-dependent and results in the inhibition of both basal and stimulated acid secretion, regardless of the stimulus.
Omezol Capsules Usage and Safety:
Dosage: Omeprazole (as prescribed by your healthcare provider).
Side Effects:
Common:
Central and Peripheral Nervous System: Headache.
Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence.
Uncommon:
Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo.
Hepatic: Increased liver enzymes.
Skin: Rash, pruritus, urticaria.
Other: Malaise.
Rare:
Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (particularly in severely ill patients).
Endocrine: Gynecomastia.
Drug Interactions: May interact with ketoconazole, itraconazole, diazepam, citalopram, imipramine, clomipramine, phenytoin, atazanavir, digoxin, clopidogrel, posaconazole, erlotinib, saquinavir, tacrolimus, methotrexate, clarithromycin, and CYP2C19 or CYP3A4 inhibitors or inducers (such as rifampicin and St. John’s Wort).
Indication:
Treatment of GERD in adults, including:
Erosive reflux esophagitis.
Long-term management to prevent relapse in patients with healed esophagitis.
Symptomatic treatment of GERD.
When Not to Use: Contraindicated in patients with known hypersensitivity to any component of the formulation or substituted benzimidazoles. Should not be used with nelfinavir.
Omezol Capsules Precautions:
Precaution: Omeprazole, like other acid-blocking medications, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. This should be monitored in patients with low body stores or risk factors for vitamin B12 deficiency during long-term therapy.
Omezol Capsules Warnings:
Gastric Malignancy: When gastric ulcer is suspected, malignancy should be ruled out as treatment may mask symptoms and delay diagnosis.
Fracture Risk: Proton pump inhibitors, particularly with long-term use or high doses beyond one year, may slightly increase the risk of hip, wrist, and spine fractures, especially in the elderly or those with other risk factors.
Hepatic Function: In patients with impaired hepatic function, consideration should be given to reducing the dose of omeprazole due to increased bioavailability and prolonged half-life.
Additional Information:
Pregnancy Category: Always consult your physician before using this medication.
Storage: Store at room temperature, away from direct light and heat.
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