Requires Prescription: Yes
Generics: Esomeprazole
Used For: Acidity & Ulcers
How It Works: Esomeprazole inhibits the final step in hydrochloric acid production by irreversibly binding to the H+/K+ ATPase enzyme in the proton pump of gastric parietal cells. This action effectively reduces gastric acid secretion and alters the stomach’s pH.
Novoteph Capsules Usage and Safety:
Dosage: Esomeprazole (as prescribed by your healthcare provider).
Side Effects:
Common: Headache, gastrointestinal upset, skin reactions, dry mouth.
Rare: Angioedema, anaphylaxis, fundic gland polyps.
Drug Interactions: May interact with phenytoin, warfarin, clopidogrel, ketoconazole, itraconazole, voriconazole, diazepam, citalopram, imipramine, clomipramine, CYP3A4 inhibitors or inducers, tacrolimus, digoxin, erlotinib, methotrexate.
Indication:
Treatment of heartburn
Gastroesophageal reflux disease (GERD)
Gastritis
Ulcers
When Not to Use:
Contraindicated in patients with known hypersensitivity to proton pump inhibitors (PPIs).
Hypersensitivity reactions such as angioedema, anaphylaxis, bronchospasm, acute interstitial nephritis, and urticaria have been reported.
Precautions:
Long-term use (beyond 3 years) may lead to malabsorption or vitamin B12 (cyanocobalamin) deficiency.
Warnings:
Hypomagnesemia has been rarely reported with prolonged PPI use.
Long-term or high-dose PPI therapy may increase the risk of osteoporosis-related fractures in the hip, wrist, or spine.
Avoid using esomeprazole with clopidogrel due to potential interaction issues.
Additional Information:
Pregnancy Category: Always consult your physician before using any medication.
Storage: Store at room temperature, away from direct light and heat.
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