Requires Prescription: Yes
Generics: Esomeprazol
Used For: Acidity & Ulcers
How It Works: Esomeprazole functions by irreversibly binding to the H+/K+ ATPase enzyme in the proton pump of the stomach’s parietal cells. This binding inhibits the final step in the secretion of hydrochloric acid, significantly reducing stomach acid production and altering gastric pH.
Usage and Safety:
Dosage: Administered according to the prescribed dosage instructions.
Side Effects: Common side effects include headache, gastrointestinal upset, skin reactions, and dry mouth. Rare side effects may include angioedema, anaphylaxis, and fundic gland polyps.
Drug Interactions: Potential interactions with phenytoin, warfarin, clopidogrel, ketoconazole, itraconazole, voriconazole, diazepam, citalopram, imipramine, clomipramine, CYP3A4 inhibitors or inducers, tacrolimus, digoxin, erlotinib, and methotrexate.
Indication: Used for treating heartburn, gastroesophageal reflux disease (GERD), gastritis, and ulcers
When Not to Use: Contraindicated in individuals with known hypersensitivity to proton pump inhibitors (PPIs). Reactions such as angioedema, anaphylaxis, bronchospasm, acute interstitial nephritis, and urticaria have been reported.
Precautions:
Long-Term Use: Prolonged daily use (e.g., beyond 3 years) may lead to vitamin B12 (cyanocobalamin) malabsorption or deficiency.
Warnings:
Hypomagnesemia: Rare cases of low magnesium levels (hypomagnesemia) have been associated with prolonged PPI use.
Fracture Risk: Extended use of PPIs, especially at high doses, may increase the risk of osteoporosis-related fractures in the hip, wrist, or spine.
Clopidogrel Interaction: Avoid using Esomeprazole concurrently with clopidogrel due to potential interactions.
Additional Information:
Pregnancy Category: Consult your physician before using this medication if you are pregnant or planning to become pregnant.
Storage: Store at room temperature, away from direct light and heat.
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