Requires Prescription: Yes

Generics: Esomeprazole

Used For: Acidity & Ulcers

How It Works: Ezium Capsules contain esomeprazole, which irreversibly binds to the H+/K+ ATPase enzyme in the proton pump of the stomach’s parietal cells. This inhibition reduces the secretion of hydrochloric acid, leading to decreased stomach acidity and altered gastric pH.

Usage and Safety:

Dosage: Follow the dosage instructions provided by your healthcare provider.

Side Effects: Common side effects include headache, gastrointestinal upset, skin reactions, and dry mouth. Rare side effects may include angioedema, anaphylaxis, and fundic gland polyps.

Drug Interactions: May interact with:

Phenytoin

Warfarin

Clopidogrel

Ketoconazole

Itraconazole

Voriconazole

Diazepam

Citalopram

Imipramine

Clomipramine

CYP3A4 inhibitors or inducers

Tacrolimus

Digoxin

Erlotinib

Methotrexate

Indications: Used for the treatment of heartburn, GERD, gastritis, and ulcers.

When Not to Use: Contraindicated in individuals with a known hypersensitivity to proton pump inhibitors (PPIs). Hypersensitivity reactions such as angioedema, anaphylaxis, bronchospasm, acute interstitial nephritis, and urticaria have been reported.

Precautions:

Long-Term Use: Extended daily use (e.g., more than 3 years) may lead to malabsorption or deficiency of vitamin B12 (cyanocobalamin).

Warnings:

Hypomagnesemia: Rarely reported with prolonged PPI use.

Osteoporosis-Related Fractures: Long-term or high-dose PPI therapy may increase the risk of fractures in the hip, wrist, or spine.

Clopidogrel Interaction: Avoid using Ezium with clopidogrel.

Additional Information:

Pregnancy Category: Consult your physician before using this medication if you are pregnant or planning to become pregnant.

Storage: Store at room temperature, away from direct light and heat.