Ezita Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Ezetimibe
Used For
Cholesterol Control
How it works
Ezetimibe decreases blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. Unlike other cholesterol-lowering compounds, ezetimibe does not inhibit cholesterol synthesis in the liver nor does it increase bile acid excretion. Ezetimibe acts at the brush border of the small intestine to inhibit the absorption of cholesterol leading to a reduction in the amount of cholesterol delivered to the liver. This in turn causes a reduction of hepatic cholesterol stores and an increase in cholesterol clearance from the blood.
Ezita Tablets Usage And Safety
Dosage
Ezetimibe
Side Effects
Body as a whole: Fatigue ; Gastrointestinal system disorders: Abdominal pain, diarrhea ; Infection and infestations: Infection viral, pharyngitis, sinusitis ; Musculo-skeletal system disorders: Arthralgia, back pain ; Respiratory system disorders: Cough
Drug Interactions
Gemfibrozil , Antacids , Cholestyramine , Fibrates , Cyclosporine .
Indication
Ezetimibe is indicated: As adjunctive therapy to diet for the reduction of elevated total-C, LDLC, and Apo B in patients with primary (heterozygous familial and nonfamilial) hypercholesterolemia as monotherapy or as combination therapy with HMG-CoA reductase inhibitors. In combination with atorvastatin or simvastatin to reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other non-pharmacological or lipid lowering treatments (e.g. LDL apheresis) or if such treatments are unavailable or inadequate ; As adjunctive therapy to diet for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia.
When not to Use
Ezetimibe is contraindicated in patients with hypersensitivity to ezetimibe or any component of the product. Ezetimibe in combination with an HMG-CoA reductase inhibitor is contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.
Ezita Tablets Precautions
Precaution
Prior to initiating therapy with ezetimibe secondary causes for dyslipidemia (i.e., diabetes, hypothyroidism, obstructive liver disease, chronic renal failure, and drugs that increase LDL-C and decrease HDL-C [progestins, anabolic steroids, and corticosteroids]), should be excluded or, if appropriate, treated .
Ezita Tablets Warnings
Warning 1
At the time of hospitalization for an acute coronary event, lipid measures should be taken on admission or within 24 hours. These values can guide the physician on initiation of LDL-lowering therapy before or at discharge.
Warning 2
Concurrent administration of ezetimibe with a specific HMG CoA reductase inhibitor should be in accordance with the product labeling for that HMG CoA reductase inhibitor.
Warning 3
When ezetimibe is co-administered with an HMG CoA reductase inhibitor, liver function tests should be performed at initiation of therapy and according to the recommendations of the HMG-CoA reductase inhibitor.
Ezita Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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