Comox Eye Specification
Requires Prescription (YES/NO)
Yes
Generics
Moxifloxacin , Dexamethasone Sodium Phosphate
Used For
Eye Infection
How it works
Moxifloxacin is a synthetic fluoroquinolone antibacterial agent active in vitro against a broad spectrum of Gram-positive and Gram-negative ocular pathogens, atypical microorganisms and anaerobes. The antibacterial action of Moxifloxacin results from inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division. Dexamethasone is a highly potent and long-acting glucocorticoid. The actions of corticosteroids are mediated by the binding of the corticosteroid molecules to receptor molecules located within sensitive cells. Corticosteroids will inhibit phospholipase A2 thereby preventing the generation of substances which mediate inflammation, for example, prostaglandins. Corticosteroids also produce a marked, though transient, lymphocytopaenia. This depletion is due to redistribution of the cells, the T lymphocytes being affected to a greater degree than the B lymphocytes. Lymphokine production is reduced, as is the sensitivity of macrophages to activation by lymphokines. Corticosteroids also retard epithelial regeneration, diminish post-inflammatory neo- vascularisation and reduce towards normal levels the excessive permeability of inflamed capillaries. The actions of corticosteroids described above are exhibited by dexamethasone and they all contribute to its anti-inflammatory effect.
Comox Eye Usage And Safety
Dosage
Moxifloxacin , Dexamethasone Sodium Phosphate
Side Effects
Conjunctival irritation , increased lacrimation , keratitis and papillary conjunctivitis, Secondary infection.
Drug Interactions
Atropine and related compounds, phenytoin, phenobarbitone, ephedrine and rifampicin.
Indication
Steroid-responsive inflammatory ocular condition for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists. Post-operative inflammation and any other ocular inflammation associated with infection.
When not to Use
It is contraindicated in patients with a history of hypersensitivity to Moxifloxacin, to other quinolones, or to any of the components in this medication.
Comox Eye Precautions
Precaution
In patients receiving systemically administered quinolones, including Moxifloxacin, serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported, some following the first dose.
Comox Eye Warnings
Warning 1
Patients should be cautioned against engaging in activities requiring complete mental alertness and motor coordination such as operating machinery until their response to these eye drops is known.
Warning 2
If an allergic reaction to Moxifloxacin occurs discontinue use of the drug. Serious acute hypersensitivity reactions may require immediate emergency treatment .
Warning 3
Adrenocortical Insufficiency Drug induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimised by gradual reduction of dosage.
Comox Eye Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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