Arnil 75 mg (Diclofenac Sodium) Tab 20’s

Diclofenac Sodium 75mg Tablet exerts its analgesic, anti-inflammatory, and antipyretic effects through multiple mechanisms. Primarily, it acts as a non-selective cyclooxygenase (COX) inhibitor, blocking both COX-1 and COX-2 enzymes. By inhibiting COX enzymes, diclofenac reduces the formation of prostaglandin precursors, which are key mediators in the inflammatory process. This inhibition leads to decreased production of prostaglandins, resulting in reduced inflammation, pain, and fever. Diclofenac’s ability to inhibit prostaglandin synthesis underlies its effectiveness in managing pain and inflammation associated with various conditions.

Diclofenac Sodium 75mg

Non-steroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Diclofenac Sodium 75mg Tablet:

• Used for relieving acute pain and inflammation caused by conditions like rheumatoid arthritis and osteoarthritis.
• Used for treating severe menstrual pain and cramps.
• Used to reduce pain and swelling after surgeries or dental procedures.
• Used for managing pain and stiffness in muscles, tendons, and joints.
• Used for alleviating pain and inflammation due to sprains, strains, or sports injuries.
• Used to reduce fever and discomfort associated with the flu or other viral infections.
• Used for short-term management of pain and inflammation in conditions where non-steroidal anti-inflammatory drugs (NSAIDs) are indicated.

Use and dose must be determined by the doctor. Usually taken once daily

In the case of an overdose of Diclofenac Sodium 75mg Tablets, individuals may experience symptoms such as nausea, vomiting, stomach pain, and in severe cases, gastrointestinal bleeding. It is important to seek medical advice promptly if an overdose is suspected. Treatment for overdose may involve supportive care, such as monitoring vital signs and providing fluids, and in some cases, gastric decontamination to remove the excess medication from the stomach. Quick action can help mitigate the potential health risks associated with this medication.

In the case of a missed dose of Diclofenac Sodium 75mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. It is important not to double the dose to make up for a missed one. If you’ve missed multiple doses, contact your healthcare provider for guidance, as they may provide specific instructions based on your medical condition and treatment plan. It’s best to establish a routine to help you remember to take your medication as prescribed.

To take Diclofenac Sodium 75mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, typically taken once or twice a day.

Diclofenac Sodium 75mg Tablet should not be used in the following conditions:

• Hypersensitivity or allergy to diclofenac or any other ingredients in the tablet.
• Active or history of gastrointestinal disorders such as peptic ulcers, gastrointestinal bleeding, or inflammatory bowel disease.
• Severe liver or kidney impairment, as diclofenac can worsen these conditions.
• Pregnant women, especially during the third trimester, as it may cause harm to the unborn child.
• Breastfeeding women, unless recommended by a healthcare provider, as it can pass into breast milk.
• Patients with a history of heart attack, stroke, or other cardiovascular diseases, as diclofenac may increase the risk of heart-related issues.
• Asthma or other respiratory disorders in individuals who have experienced asthma attacks, urticaria, or allergic-type reactions after taking NSAIDs.
• Individuals taking other NSAIDs or blood-thinning medications, as they may increase the risk of side effects such as bleeding.

The side effects of Diclofenac Sodium 75mg Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Skin rash or itching
• Increased blood pressure
• Liver problems (e.g., elevated liver enzymes)

Following are the precautions and warnings for Diclofenac Sodium 75mg Tablet:

• This medication should be used with caution in patients with a history of gastrointestinal bleeding or ulcers. Regular monitoring is necessary for these conditions.
• Patients with cardiovascular risks such as high blood pressure, high cholesterol, or diabetes should exercise caution and be regularly monitored while on this medication.
• It may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. These risks are higher with long-term use and in higher doses.
• Diclofenac Sodium can cause liver problems. Monitor liver function regularly, especially in long-term use.
• Not recommended for individuals with severe heart failure, as it may worsen their condition.
• Elderly patients are more prone to the adverse effects of this medication, particularly gastrointestinal bleeding and perforation.
• Avoid during pregnancy, especially in the third trimester, as it may cause premature closure of the ductus arteriosus. Consult a healthcare professional for advice.
• Breastfeeding women should use this medication with caution as it can pass into breast milk and may have adverse effects on the infant.

Following are the drug interactions for Diclofenac Sodium 75mg Tablet:

• Concomitant use with ACE inhibitors or angiotensin II receptor blockers (ARBs) may decrease their effectiveness in lowering blood pressure.
• Can reduce the efficacy of diuretics and antihypertensive drugs due to sodium and fluid retention.
• Lithium levels may increase, leading to lithium toxicity.
• When taken with methotrexate, it can increase the risk of methotrexate toxicity.
• May increase plasma concentrations of digoxin, requiring monitoring.
• Potentially increases the risk of bleeding when used with anticoagulants like warfarin.
• May decrease the renal excretion of ciclosporin, potentially increasing its toxicity.

Following are the food interactions for Diclofenac Sodium 75mg Tablet:

• Avoid excessive alcohol consumption as it may increase the risk of gastrointestinal bleeding and liver problems.
• Limit the intake of foods high in sodium (salt) to prevent fluid retention and hypertension.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Diclofenac, potentially increasing its levels in the body.
• Avoid caffeine-rich foods and beverages as they may enhance the drug’s effects and increase the risk of side effects like nervousness and insomnia.
• Avoid herbal supplements like Ginkgo Biloba and Garlic, as they may increase the risk of bleeding.
• Limit fatty and fried foods to reduce the strain on the digestive system and promote better absorption of the medication.
• Avoid potassium-rich foods like bananas and oranges if you have kidney issues, as Diclofenac can affect potassium levels.

Diclofenac Sodium 75mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Maintain the tablets in their original container, tightly sealed, to ensure their integrity and protect them from environmental factors. It is crucial not to expose the tablets to extreme temperatures, so avoid storing them in hot or humid environments like bathrooms or near heating appliances. Regularly check the expiration date on the packaging, and if the tablets have passed their expiry, dispose of them safely. Do not flush the medication or pour it into drainage systems; instead, follow local guidelines or consult a pharmacist for appropriate disposal methods. Always keep medications out of children’s reach to prevent accidental consumption.