Requires Prescription: Yes
Generics:
Vonoprazan
Used For:
Acidity and ulcers
How It Works:
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that does not need activation by acid. It reversibly inhibits H+, K+-ATPase in a potassium-competitive manner. With strong basicity, it binds to the acid production site in gastric parietal cells, thereby significantly reducing gastric acid production and protecting against mucosal damage in the upper gastrointestinal tract.
Usage and Safety:
Dosage:
As prescribed for Vonoprazan.
Side Effects:
Gastrointestinal: Diarrhea, constipation, nausea, abdominal distension
Dermatologic: Rash, urticaria, drug eruption
Hepatic: Hepatotoxicity, jaundice, elevated liver enzymes (AST, ALT, ALP, GGT, LDH)
Other: Drug hypersensitivity (including anaphylactic shock), edema, eosinophilia
Drug Interactions:
CYP3A4 inhibitors such as Clarithromycin, Digoxin, Methyldigoxin, Itraconazole
Tyrosine kinase inhibitors including Gefitinib, Nilotinib, Erlotinib
Indications:
Gastric ulcer
Duodenal ulcer
Reflux esophagitis
Prevention of recurrence of gastric or duodenal ulcers during low-dose aspirin or NSAID use
Contraindications:
Hypersensitivity to Vonoprazan or any excipient
Concurrent use with atazanavir sulfate, nelfinavir, or rilpivirine hydrochloride
Precautions:
Monitor the patient closely and use the minimum effective dose necessary for the condition.
Warnings:
Reflux Esophagitis: Use Vonoprazan only for patients with recurrent or persistent reflux esophagitis. Avoid administration in patients not requiring maintenance therapy.
Long-Term Use: Consider reducing the dose from 20 mg to 10 mg or discontinuing if the condition is stable and there is no risk of recurrence.
Renal Disorders: Administer with caution in patients with renal disorders due to potential delays in excretion, which may increase Vonoprazan blood levels.
Pregnancy Category:
Consult your physician before use if pregnant.
Storage:
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