Requires Prescription: Yes
Generics:
Vonoprazan
Used For:
Acidity and ulcers
How It Works:
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits H+, K+-ATPase in a reversible and potassium-competitive manner. It maintains a strong presence at the acid production site in gastric parietal cells, effectively reducing gastric acid production and preventing mucosal damage in the upper gastrointestinal tract.
Usage and Safety:
Dosage:
As prescribed for Vonoprazan.
Side Effects:
Gastrointestinal: Diarrhea, constipation, nausea, abdominal distension
Skin: Rash, urticaria, drug eruption
Hepatic: Hepatotoxicity, jaundice, elevated liver enzymes (AST, ALT, ALP, GGT, LDH)
Other: Drug hypersensitivity (including anaphylactic shock), edema, eosinophilia
Drug Interactions:
CYP3A4 inhibitors such as Clarithromycin, Digoxin, Methyldigoxin, Itraconazole
Tyrosine kinase inhibitors like Gefitinib, Nilotinib, Erlotinib
Indications:
Gastric ulcer
Duodenal ulcer
Reflux esophagitis
Prevention of recurrence of gastric or duodenal ulcers during low-dose aspirin or NSAID use
When Not to Use:
Hypersensitivity to Vonoprazan or any excipient
Concurrent use with atazanavir sulfate, nelfinavir, or rilpivirine hydrochloride
Precautions:
Monitor the patient closely and use the minimum effective dose necessary for the condition.
Warnings:
For maintenance of reflux esophagitis healing, use Vonoprazan only in patients with recurrent or persistent symptoms. Avoid use in those who do not need ongoing treatment.
Consider reducing the dose from 20 mg to 10 mg or discontinuing if long-term maintenance is not needed and there is no risk of recurrence.
Administer with caution in patients with renal disorders due to potential delays in excretion, which may increase Vonoprazan blood levels.
Pregnancy Category:
Consult your physician before use if pregnant.
Storage:
Store at room temperature, away from direct light and heat.
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