Prescription Required: Yes
Generics:
Vonoprazan
Uses:
Treats acidity and ulcers
How It Works:
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits H+, K+-ATPase in a reversible, potassium-competitive manner without needing activation by acid. It maintains a strong basicity and binds to the acid production site in gastric parietal cells, leading to prolonged inhibition of gastric acid production and prevention of mucosal damage in the upper gastrointestinal tract.
Dosage:
As prescribed for Vonoprazan.
Side Effects:
Gastrointestinal: Diarrhea, constipation, nausea, abdominal distension
Skin: Rash, urticaria, drug eruption
Hepatic: Hepatotoxicity, jaundice, increased liver enzymes (AST, ALT, ALP, GGT, LDH)
Other: Drug hypersensitivity (including anaphylactic shock), edema, eosinophilia
Drug Interactions:
May interact with CYP3A4 inhibitors such as Clarithromycin, Digoxin, Methyldigoxin, Itraconazole, and tyrosine kinase inhibitors (e.g., Gefitinib, Nilotinib, Erlotinib).
Indications:
Gastric ulcer
Duodenal ulcer
Reflux esophagitis
Prevention of recurrence of gastric or duodenal ulcers during low-dose aspirin or NSAID use
When Not to Use:
Hypersensitivity to Vonoprazan or any excipient
Concurrent use with atazanavir sulfate, nelfinavir, or rilpivirine hydrochloride
Precautions:
Monitor the patient’s condition closely and use the minimum effective dose necessary.
Warnings:
For maintaining healing of reflux esophagitis, use Vonoprazan only in patients with recurrent symptoms. Avoid use in patients not needing maintenance therapy.
Consider reducing the dose from 20 mg to 10 mg or discontinuing treatment if long-term maintenance is not required and there is no risk of recurrence.
Use with caution in patients with renal disorders due to potential delays in excretion, which may increase blood concentrations of Vonoprazan.
Pregnancy Category:
Consult your physician before use if pregnant.
Storage:
Store at room temperature, away from direct light and heat.
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