Prescription Required: Yes
Generics:
Vonoprazan
Uses:
Treats acidity and ulcers
How It Works:
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits H+, K+-ATPase in a reversible, potassium-competitive manner. It maintains a long-term presence at the acid production site in gastric parietal cells, strongly reducing gastric acid production and preventing mucosal damage in the upper gastrointestinal tract.
Dosage:
As prescribed for Vonoprazan.
Side Effects:
Gastrointestinal: Diarrhea, constipation, nausea, abdominal distension
Skin: Rash, urticaria, drug eruption
Hepatic: Hepatotoxicity, jaundice, increased liver enzymes (AST, ALT, ALP, GGT, LDH)
Other: Drug hypersensitivity (including anaphylactic shock), edema, eosinophilia
Drug Interactions:
May interact with CYP3A4 inhibitors such as Clarithromycin, Digoxin, Methyldigoxin, Itraconazole, Tyrosine kinase inhibitors (e.g., Gefitinib, Nilotinib, Erlotinib).
Indications:
Gastric ulcer
Duodenal ulcer
Reflux esophagitis
Prevention of recurrence of gastric or duodenal ulcers during low-dose aspirin or NSAID use
When Not to Use:
Hypersensitivity to Vonoprazan or any excipient in the product
Patients on atazanavir sulfate, nelfinavir, or rilpivirine hydrochloride
Precautions:
Monitor the disease course closely and use the minimum effective dose according to the condition.
Warnings:
For maintaining healing of reflux esophagitis, Vonoprazan should only be used in patients who experience recurrence. Avoid use in patients not requiring maintenance.
Consider reducing the dose from 20 mg to 10 mg or discontinuing if long-term maintenance is not needed.
Use with caution in patients with renal disorders due to potential increased blood concentration of Vonoprazan.
Pregnancy Category:
Consult your physician before use if pregnant.
Storage:
Store at room temperature, away from direct light and heat.
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