Vermox 500 mg (Mebendazole) Tab 12’s

Mebendazole, a medication found in the 500mg tablet, functions as an anthelmintic agent, specifically targeting parasitic worms. Its primary mechanism of action involves binding to the colchicine-sensitive site of β-tubulin, a protein subunit of microtubules in the intestinal cells of parasites. This binding action inhibits microtubule polymerization, which is essential for the formation of the cytoskeleton and various cellular processes in the parasites. By disrupting microtubule function, Mebendazole impairs the parasite’s ability to uptake glucose, thereby depleting its glycogen stores and leading to energy depletion and eventual death of the parasite. This selective action makes Mebendazole effective against a range of intestinal parasites, primarily by targeting their microtubular structure and vital cellular functions.

Mebendazole 500mg

Anthelmintic

Tablet

The following are the uses of Mebendazole 500mg Tablet:

• Used for treating pinworms, roundworms, whipworms, and hookworms infections.
• Used for managing ascariasis, enterobiasis, trichuriasis, and hookworm infections.
• Used for eliminating parasitic worms from the body.
• Used for preventing reinfection and reducing transmission.
• Used for providing relief from gastrointestinal symptoms caused by worm infections.
• Used for treating multiple infections simultaneously.
• Used for both children and adults, as directed by a healthcare professional.
• Used for completing the full course as prescribed for effective treatment.

To be taken as per doctor’s prescription

In the case of an overdose of Mebendazole 500mg Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and dizziness. It is important to recognize that taking more than the recommended dosage can lead to adverse effects. If an overdose is suspected, prompt medical advice should be sought. Medical professionals may induce vomiting or administer activated charcoal to minimize further absorption of the medication. Timely intervention and treatment are essential to manage any potential complications effectively.

In the case of a missed dose of Mebendazole 500mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to proceed and ensure the treatment remains effective. It is generally recommended to try to take the medication at the same time each day to maintain a consistent level in your system.

To take Mebendazole 500mg Tablet, swallow the tablet whole with a full glass of water, preferably during or after a meal, following the prescribed dosage provided by your healthcare professional, typically a single dose or as directed by your doctor.

Here are the conditions or situations when Mebendazole 500mg Tablet should not be used:

• Avoid using in individuals with a known hypersensitivity or allergy to Mebendazole or other similar medications.
• Contraindicated in patients with liver disease or impaired liver function.
• Should not be taken during pregnancy or by breastfeeding mothers.
• Not recommended for individuals with blood disorders or compromised bone marrow function.
• Avoid using in patients with a known history of intestinal obstruction or other gastrointestinal issues.
• Not suitable for individuals with known or suspected strongyloidosis (a parasitic infection).
• Should not be used in patients with known or suspected liver fluke infections.
• Contraindicated in patients with a history of anaphylactic reactions to benzimidazoles.

The side effects of Mebendazole 500mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Hair loss
• Skin rashes or itching

Following are the precautions and warnings for Mebendazole 500mg Tablet:

• Do not use in patients with known hypersensitivity or allergy to Mebendazole or any of its components.
• Mebendazole should be used with caution in patients with liver disease as it is primarily metabolized by the liver. Regular monitoring of liver function is recommended during treatment.
• Not recommended for pregnant women, especially during the first trimester. It should only be used if the potential benefits outweigh the risks.
• Avoid breastfeeding while using Mebendazole as it can pass into breast milk and potentially harm the infant.
• This medication may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you feel normal.
• Elderly patients may be more sensitive to the side effects; dosage adjustments might be necessary.
• Always complete the full course of treatment to ensure the parasite infection is completely eliminated.
• Keep Mebendazole out of reach of children and pets.

Following are the drug interactions for Mebendazole 500mg Tablet:

• Mebendazole can reduce the effectiveness of oral contraceptives, potentially leading to an increased risk of pregnancy.
• It may decrease the plasma concentration of antimalarial drugs like praziquantel, reducing their efficacy.
• Co-administration with metronidazole can lead to an increased risk of neurotoxicity, including dizziness, confusion, and ataxia.
• The absorption of Mebendazole is significantly reduced when taken with antacids containing aluminum or magnesium hydroxide.
• Carbamazepine can decrease Mebendazole plasma levels, potentially reducing its effectiveness.
• Cimetidine, a CYP3A4 inhibitor, may increase the plasma concentration of Mebendazole, leading to enhanced side effects.
• Mebendazole may interact with anticoagulants, requiring close monitoring of prothrombin time and INR.
• It may also interact with certain antifungal medications, such as griseofulvin, potentially affecting the efficacy of both drugs.

Following are the food interactions for Mebendazole 500mg Tablet:

• Mebendazole absorption can be significantly reduced by consuming high-fat meals, so it is best to take the medication on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of Mebendazole, potentially leading to increased drug levels in the body and an elevated risk of side effects.
• Alcohol consumption is not recommended during treatment with Mebendazole, as it may increase the risk of liver-related side effects and could potentially reduce the drug’s effectiveness.
• Avoid consuming dairy products like milk, cheese, and yogurt close to taking Mebendazole, as calcium can bind with the medication and reduce its absorption.
• Foods rich in vitamin C, such as citrus fruits and broccoli, might decrease Mebendazole’s effectiveness by promoting its breakdown.
• Fatty foods and fried items should be minimized as they can slow down the absorption and effectiveness of the medication.
• Mebendazole may interact with antacid medications containing magnesium or aluminum, so it is best to separate the consumption of these antacids and Mebendazole by at least 2 hours.
• Certain types of nuts and seeds, including peanuts and flaxseeds, may interfere with Mebendazole’s absorption and should be consumed in moderation during treatment.

Mebendazole 500mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to avoid storing them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact the medication’s effectiveness. Proper disposal is essential; do not flush the tablets or throw them into the garbage. Consult your pharmacist or local waste management guidelines for the recommended disposal method. Always keep medications out of children’s reach to prevent accidental consumption