Sante Capsules 40Mg (1 Strip = 7 Capsules)

Requires Prescription: Yes

Generics: Omeprazole

Used For: Gastroesophageal Reflux Disease (GERD)

How It Works:

Omeprazole reduces gastric acid secretion by irreversibly inhibiting the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, also known as the proton pump, in the gastric parietal cells. This mechanism results in a dose-dependent suppression of both basal and stimulated acid secretion, regardless of the stimulus.

Sante Capsules Usage and Safety:

Dosage:

Omeprazole

Side Effects:

Common:

Central and Peripheral Nervous System: Headache

Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence

Uncommon:

Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo

Hepatic: Increased liver enzymes

Skin: Rash, pruritis, urticaria

Other: Malaise

Rare:

Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (more common in severely ill patients)

Endocrine: Gynecomastia

Drug Interactions:

Ketoconazole, itraconazole

Diazepam, citalopram, imipramine, clomipramine

Phenytoin

Atazanavir

Digoxin, clopidogrel

Posaconazole, erlotinib, saquinavir

Tacrolimus, methotrexate

Clarithromycin

CYP2C19 or CYP3A4 inhibitors/inducers (e.g., rifampicin, St. John’s Wort)

Indication:

Treatment of erosive reflux esophagitis

Long-term management of healed esophagitis to prevent relapse

Symptomatic treatment of gastroesophageal reflux disease (GERD)

When Not to Use:

Contraindicated in patients with known hypersensitivity to any component of the formulation or substituted benzimidazoles

Must not be used with nelfinavir

Sante Capsules Precautions:

Precaution:

Omeprazole, like other acid-blocking medications, may impair vitamin B12 (cyanocobalamin) absorption due to reduced gastric acid levels. This is important to consider in patients with low body stores or those at risk of impaired vitamin B12 absorption during long-term therapy.

Sante Capsules Warnings:

Warning 1:

When a gastric ulcer is suspected, malignancy should be ruled out as omeprazole may alleviate symptoms and potentially delay diagnosis.

Warning 2:

Prolonged use or high doses of proton pump inhibitors (beyond one year) may modestly increase the risk of hip, wrist, and spine fractures, particularly in the elderly or those with other risk factors.

Warning 3:

In patients with impaired hepatic function, dose adjustments may be necessary due to increased bioavailability and half-life of omeprazole.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medication.

Storage:

Store at room temperature, away from direct light and heat.