Risek Iv Injection 40Mg (1 Box = 1 Injection)

Requires Prescription: Yes

Generics: Omeprazole

Used For: Gastroesophageal Reflux Disease (GERD)

How It Works:

Omeprazole reduces gastric acid secretion by irreversibly blocking the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), also known as the proton pump, in gastric parietal cells. This mechanism of action leads to a dose-dependent inhibition of both basal and stimulated acid secretion, regardless of the stimulus.

Risek IV Usage and Safety:

Dosage:

Omeprazole

Side Effects

Common:

Central and Peripheral Nervous System: Headache

Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence

Uncommon:

Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo

Hepatic: Increased liver enzymes

Skin: Rash, pruritis, urticaria

Other: Malaise

Rare:

Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (predominantly in severely ill patients)

Endocrine: Gynecomastia

Drug Interactions:

Ketoconazole, itraconazole

Diazepam, citalopram, imipramine, clomipramine

Phenytoin

Atazanavir

Digoxin, clopidogrel

Posaconazole, erlotinib, saquinavir

Tacrolimus, methotrexate

Clarithromycin

CYP2C19 or CYP3A4 inhibitors/inducers (e.g., rifampicin, St. John’s Wort)

Indication:

Treatment of erosive reflux esophagitis

Long-term management of patients with healed esophagitis to prevent relapse

Symptomatic treatment of gastroesophageal reflux disease (GERD)

When Not to Use:

Contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles

Must not be used with nelfinavir

Risek IV Precautions:

Precaution:

Omeprazole, like other acid-blocking medications, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. This should be considered for patients with reduced body stores or risk factors for vitamin B12 deficiency during long-term therapy.

Risek IV Warnings:

Warning 1:

If a gastric ulcer is suspected, the possibility of malignancy should be ruled out, as treatment may alleviate symptoms and delay diagnosis.

Warning 2:

Long-term use of proton pump inhibitors, especially at high doses, may modestly increase the risk of fractures (hip, wrist, spine), particularly in elderly patients or those with other risk factors.

Warning 3:

Dose adjustments may be necessary for patients with impaired hepatic function, as omeprazole’s bioavailability and half-life can be increased.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medicine.

Storage:

Store at room temperature, away from direct light and heat.