Peridone Tablets 10Mg (1 Box = 1 Strip)(1 Strip = 30 Tablets)

Requires Prescription: Yes

Generics: Domeperidone

Used For: Nausea & Vomiting

How It Works:

Peridone’s antiemetic effect is attributed to its peripheral (gastrokinetic) actions and its antagonism of dopamine receptors in the chemoreceptor trigger zone, located outside the blood-brain barrier in the area postrema.

Peridone Tablets Usage and Safety:

Dosage: Domeperidone

Side Effects:

Common: Headache (5.6%), Diarrhea (5.2%), Breast Enlargement/Gynaecomastia (5.3%), Breast Tenderness (4.4%), Galactorrhea (3.3%), Amenorrhea (2.9%)

Less Common: Depression (2.5%), Somnolence (2.5%), Rash (2.8%), Pruritus (1.7%), Akathisia (1%), Libido Decreased/Loss of Libido, Menstruation Irregular (2.0%), Lactation Disorder (1.6%)

Drug Interactions:

CYP3A4 inhibitors (e.g., indinavir)

Antiarrhythmics (e.g., disopyramide, amiodarone)

Certain antipsychotics (e.g., haloperidol)

Certain antidepressants (e.g., citalopram)

Certain antibiotics (e.g., levofloxacin)

Certain antifungal agents (e.g., pentamidine)

Certain antimalarial agents (e.g., halofantrine)

Gastrointestinal drugs (e.g., dolasetron)

Cancer drugs (e.g., toremifene)

Other drugs (e.g., methadone)

Indication: Used for the treatment of nausea and vomiting.

When Not to Use:

Contraindicated in patients with moderate to severe hepatic impairment, existing cardiac conduction interval prolongation (particularly QTc), significant electrolyte disturbances, or underlying cardiac diseases (e.g., congestive heart failure).

Peridone Tablets Precautions:

Precaution: Epidemiological studies suggest an increased risk of serious ventricular arrhythmias or sudden cardiac death associated with domeperidone.

Peridone Tablets Warnings:

Warning 1: Patients over 60 years old should consult a physician before using domeperidone.

Warning 2: Not recommended for patients with known QTc interval prolongation or significant electrolyte imbalances due to an increased risk of ventricular arrhythmia.

Warning 3: Discontinue use if signs or symptoms of cardiac arrhythmia occur and consult a physician immediately.

Additional Information:

Pregnancy Category: Always consult your physician before use.

Storage: Store at room temperature, away from direct light and heat.