Onseget Im/Iv Injection 4Mg (1 Box = 1 Injection)

Requires Prescription: Yes

Generics: Ondansetron

Used For: Nausea & Vomiting

How it Works:

Ondansetron is a selective antagonist of the 5-HT3 serotonin receptor subtype. It is used to manage nausea and vomiting, particularly in chemotherapy settings. Although its exact mechanism of action is not fully understood, it is believed to work by blocking serotonin receptors that trigger nausea and vomiting. The release of serotonin from the small intestine in response to chemotherapy might stimulate 5-HT3 receptors on vagal afferents, initiating a vomiting reflex. Ondansetron may inhibit this reflex. Additionally, serotonin release in the central nervous system could contribute to its antiemetic effects.

Dosage: Refer to the specific dosing guidelines for ondansetron.

Side Effects:

Chemotherapy-Induced Nausea and Vomiting: Diarrhea, headache, fever, constipation, rash. Rarely: angina, ECG changes, hypotension, tachycardia, QT prolongation, ST segment depression, bradycardia, transient liver enzyme elevations, neurological effects like seizures or extrapyramidal reactions, and hypokalemia.

Postoperative Nausea and Vomiting: Headache, drowsiness/sedation, injection site reactions, fever, cold sensation, pruritus, paresthesia. Rarely: pain, redness, burning at the injection site, hiccups, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, transient blindness, oculogyric crisis, and dizziness.

Drug Interactions:

Cytochrome P-450 Enzyme Modifiers: Apomorphine, phenytoin, carbamazepine, rifampin.

Serotonergic Drugs: Carbetapentane, tramadol.

Chemotherapy Agents: Carmustine, etoposide, cisplatin.

Others: Temazepam, alfentanil, atracurium.

Indication:

Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

When Not to Use:

Ondansetron is contraindicated in patients with known hypersensitivity to the drug or its components. The concurrent use of ondansetron with apomorphine is contraindicated due to the risk of profound hypotension and loss of consciousness.

Precautions:

Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who are sensitive to other 5-HT3 receptor antagonists.

Warnings:

Ondansetron can prolong the QT interval in a dose-dependent manner. It should be avoided in patients with congenital long QT syndrome. ECG monitoring is advised for patients with electrolyte imbalances (e.g., hypokalemia, hypomagnesemia), heart failure, bradyarrhythmias, or those on other QT-prolonging drugs.

Ondansetron may mask symptoms of progressive ileus and gastric distention in patients undergoing abdominal surgery or experiencing chemotherapy-induced nausea and vomiting.

Ondansetron does not stimulate gastric or intestinal peristalsis and should not replace nasogastric suction.

Additional Information:

Pregnancy Category: Consult your physician before using any medicine during pregnancy.

Storage: Store at room temperature, away from direct light and heat.