Requires Prescription: Yes
Generics: Omeprazole + Sodium Bicarbonate
Used For: Gastroesophageal Reflux Disease (GERD)
How It Works: Omeprazole reduces gastric acid secretion by irreversibly blocking the H+/K+ ATPase enzyme system (the proton pump) in gastric parietal cells. This inhibition affects both basal and stimulated acid secretion, regardless of the stimulus. Sodium bicarbonate works as an antacid to neutralize stomach acid, providing additional relief.
Omega Rapid Usage and Safety:
Dosage: Omeprazole + Sodium Bicarbonate (as prescribed by your healthcare provider).
Side Effects:
Common:
Central and Peripheral Nervous System: Headache.
Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence.
Uncommon:
Central and Peripheral Nervous System: Dizziness, paraesthesia, somnolence, insomnia, vertigo.
Hepatic: Increased liver enzymes.
Skin: Rash, pruritus, urticaria.
Other: Malaise.
Rare:
Central and Peripheral Nervous System: Reversible mental confusion, agitation, aggression, depression, hallucinations (particularly in severely ill patients).
Endocrine: Gynecomastia.
Drug Interactions: May interact with ketoconazole, itraconazole, diazepam, citalopram, imipramine, clomipramine, phenytoin, atazanavir, digoxin, clopidogrel, posaconazole, erlotinib, saquinavir, tacrolimus, methotrexate, clarithromycin, and CYP2C19 or CYP3A4 inhibitors or inducers (e.g., rifampicin, St. John’s Wort).
Indication:
Treatment of GERD in adults, including:
Erosive reflux esophagitis.
Long-term management to prevent relapse in patients with healed esophagitis.
Symptomatic treatment of GERD.
When Not to Use: Contraindicated in patients with hypersensitivity to any component of the formulation or substituted benzimidazoles. Should not be used with nelfinavir.
Omega Rapid Precautions:
Precaution: A symptomatic response to therapy with omeprazole does not rule out the presence of gastric malignancy.
Omega Rapid Warnings:
Atrophic Gastritis: Long-term use of omeprazole may occasionally be associated with atrophic gastritis as seen in gastric corpus biopsies.
Sodium Bicarbonate Caution: Use sodium bicarbonate with caution in patients with Bartter’s syndrome, hypokalemia, respiratory alkalosis, or issues with acid-base balance. Long-term use with calcium or milk can lead to milk-alkali syndrome.
Sodium Content: Omeprazole powder for oral suspension contains sodium in the form of sodium bicarbonate, which should be considered for patients on a sodium-restricted diet.
Additional Information:
Pregnancy Category: Always consult your physician before using this medication.
Storage: Store at room temperature, away from direct light and heat.
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