Nevanac (Nepafenac) Eye Drop 5 ml

Nepafenac, a non-steroidal anti-inflammatory drug (NSAID), primarily acts by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are involved in the synthesis of prostaglandins. When administered in the form of eye drops, nepafenac penetrates the cornea and undergoes rapid metabolism to amfenac, its active form. Amfenac selectively blocks the COX enzymes, particularly COX-2, which is responsible for the production of inflammatory mediators such as prostaglandins and thromboxanes. By inhibiting the production of these inflammatory substances, nepafenac helps reduce pain, inflammation, and ocular discomfort associated with various eye conditions. This mechanism of action makes nepafenac effective in managing postoperative inflammation and pain following cataract surgery or other ocular procedures.

Nonsteroidal anti-inflammatory drug (NSAID)

Drop

The following are the uses of Nepafenac Drop:

• Used for reducing pain and inflammation after cataract surgery or other eye surgeries.
• Used to treat swelling and inflammation in the eye.
• Used for managing post-operative eye pain.
• Used to alleviate eye redness and irritation.
• Used for preventing and treating ocular allergies.
• Used to relieve symptoms of eye injuries or infections.
• Used for long-term management of chronic eye conditions.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Nepafenac 0.1% is commonly used as eye drops to relieve inflammation and pain in certain eye conditions.
• The usual dosage is one drop in the affected eye(s) for anterior uveitis (inflammation of the front part of the eye), and one drop in the operated eye(s) for postoperative inflammation, twice a day.

In the case of an overdose of Nepafenac Drops, it is important to remain calm and take prompt action. Contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions based on the amount ingested and individual factors. Quick response can help mitigate potential adverse effects, as healthcare providers may recommend appropriate measures such as inducing vomiting or administering activated charcoal to minimize the impact of the overdose.

In the case of a missed dose of Nepafenac Drops, it is important to administer the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It is best to use the medication at evenly spaced intervals as prescribed by your healthcare professional. If you have any concerns or frequently miss doses, consult your doctor or pharmacist for guidance on how to adjust your dosing schedule.

To administer Nepafenac eye drops, gently tilt your head back, hold the dropper close to your eye, and place the prescribed number of drops into the lower eyelid, then close your eyes for 1-2 minutes to allow the medication to absorb.

Here are the conditions or situations when Nepafenac eye drops should not be used:

• Do not use if you have a known allergy or sensitivity to Nepafenac or any other ingredients in the eye drop formulation.
• Contraindicated in patients with active eye infections or inflammation such as uveitis or conjunctivitis.
• Not suitable for individuals with a history of corneal ulcers or recent eye surgery.
• Should not be used if you have a torn or damaged lens in your eye.
• Avoid using if you have a history of severe dry eye syndrome or severe ocular surface disease.
• Not recommended for individuals with narrow-angle glaucoma or a history of angle-closure glaucoma.
• Contraindicated during pregnancy or breastfeeding, unless the potential benefits outweigh the risks.
• Not suitable for children or adolescents under the age of 18 years.

The side effects of Nepafenac Eye Drops may include:

• Itching or redness in the eyes
• Temporary burning or stinging sensation
• Increased sensitivity to light (photophobia)
• Blurred vision or changes in vision
• Eye discharge or watering
• Dry eyes
• Swelling or inflammation of the eyelids

Following are the precautions and warnings for Nepafenac Eye Drops:

• This medication is for ophthalmic use only and should never be ingested or injected.
• Wash your hands before and after using the eye drops to maintain proper hygiene.
• Contact lenses should be removed before applying the eye drops and can be reinserted after 15 minutes.
• Avoid touching the dropper tip to the eye or any surface to prevent contamination.
• If you have existing eye infections or injuries, consult your doctor before using Nepafenac.
• Discontinue use and seek medical attention if you experience severe eye pain, changes in vision, or signs of an allergic reaction.
• Keep out of reach of children and pets. Store at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Nepafenac Eye Drops:

• Probenecid and sulfinpyrazone may increase the concentration of nepafenac in the body, potentially leading to increased side effects.
• Nepafenac may enhance the anticoagulant effect of warfarin, requiring close monitoring of prothrombin time.
• Concomitant use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of systemic adverse events.
• Topical corticosteroids should be used cautiously with nepafenac, as they may increase the risk of corneal complications.
• It is advisable to avoid using other topical ophthalmic medications while using nepafenac to prevent washout.
• The use of nepafenac with other prostaglandin analogs may increase ocular side effects.
• Antihypertensive medications might have their effects diminished when used with nepafenac.

Following are the food interactions for Nepafenac Drops:

• Avoid consuming alcohol while using Nepafenac as it can increase the risk of stomach bleeding and liver toxicity.
• Nepafenac may cause stomach irritation, so it’s best to avoid spicy foods, citrus fruits, and other acidic items that can aggravate the stomach.
• Caffeine intake should be limited as it can increase the risk of side effects like nervousness, insomnia, and palpitations.
• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of Nepafenac, leading to increased drug levels in the body.
• Dairy products may decrease the absorption of Nepafenac, so consider separating milk, cheese, and yogurt consumption from the medication by a few hours.
• Foods rich in Vitamin K, like leafy green vegetables, can potentially reduce the effectiveness of Nepafenac’s blood-thinning effects.
• Avoid high-sodium foods, as Nepafenac may cause sodium retention, leading to increased blood pressure.
• Consuming a healthy, balanced diet is generally recommended to support overall health while using Nepafenac.

Nepafenac eye drops should be stored properly to maintain their effectiveness and safety. Keep the unopened bottles in a cool, dry place, preferably between 68°F and 77°F (20°C and 25°C). Once opened, store the bottle in an upright position at room temperature, away from excessive heat and direct sunlight. It is crucial not to freeze the eye drops. Always replace the cap tightly after each use to prevent contamination. Before applying the drops, check the liquid for any discoloration or particles. If you notice any signs of deterioration or if the drops have passed their expiration date, do not use them and dispose of them properly. Consult your pharmacist or healthcare provider for appropriate disposal methods, and keep the medication away from children to prevent accidental exposure.

Following are the quick tips for Nepafenac Drops:

• Wash your hands before administering the drops to maintain hygiene.
• Tilt your head back slightly and gently pull down the lower eyelid to create a pocket.
• Hold the dropper above the eye and squeeze out the prescribed number of drops into the pocket.
• Close your eye gently and press the inner corner of the eye with your finger for 1-2 minutes to prevent drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If using other eye medications, wait at least 5 minutes before applying the next medication.
• Store the drops in a cool, dry place, away from direct sunlight and heat.

When taking Nepafenac 0.1%, it is vital to undergo specific laboratory tests to ensure your safety and adjust the dosage if required. These tests are crucial due to the potential stress on your liver and kidneys from the medication. Among the critical tests are a liver function test, kidney function test, and an eye examination. The liver function test helps assess the liver’s well-being, examining enzymes such as ALT and AST, which indicate liver injury. The kidney function test, consisting of blood urea nitrogen and creatinine measurements, is necessary to monitor stress on the kidneys caused by Nepafenac 0.1%’s excretion.Regular eye exams are advised to monitor the condition’s progression and the medication’s efficacy. These exams assess eye pressure, visual acuity, and eye redness to ensure the eyes respond suitably to the treatment.