Requires Prescription: Yes
Generics: Omeprazole
Used For: Gastroesophageal Reflux Disease (GERD)
How it works: Helezol Capsules inhibit gastric acid secretion by irreversibly blocking the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system in gastric parietal cells. This leads to reduced acid secretion regardless of the stimulus, both basal and stimulated.
Helezol Capsules Usage and Safety:
Dosage: Follow the prescribed dosage of Omeprazole.
Side Effects:
Common: Headache, diarrhea, constipation, abdominal pain, nausea/vomiting, flatulence.
Uncommon: Dizziness, paraesthesia, somnolence, insomnia, vertigo, increased liver enzymes, rash, pruritis, urticaria, malaise.
Rare: Reversible mental confusion, agitation, aggression, depression, hallucinations (mainly in severely ill patients), gynecomastia.
Drug Interactions:
Ketoconazole, itraconazole
Diazepam, citalopram, imipramine, clomipramine, phenytoin
Atazanavir, digoxin, clopidogrel, posaconazole, erlotinib, saquinavir, tacrolimus, methotrexate, clarithromycin
CYP2C19 or CYP3A4 inhibitors (e.g., rifampicin, St John’s wort)
Indication:
Treatment of GERD, including erosive reflux esophagitis.
Long-term management to prevent relapse in patients with healed esophagitis.
Symptomatic treatment of GERD.
When Not to Use:
Contraindicated in patients with hypersensitivity to any component or substituted benzimidazoles.
Not to be used with nelfinavir.
Helezol Capsules Precautions
Precaution: Long-term use may reduce vitamin B12 absorption due to reduced gastric acid, which should be monitored in patients with risk factors for vitamin B12 deficiency.
Helezol Capsules Warnings:
Warning 1: Exclude malignancy in patients with suspected gastric ulcers as treatment may mask symptoms and delay diagnosis.
Warning 2: Prolonged use, especially at high doses, may increase the risk of hip, wrist, and spine fractures, particularly in the elderly or those with other risk factors.
Warning 3: Reduce dosage in patients with impaired hepatic function as bioavailability and half-life may be increased.
Helezol Capsules Additional Information:
Pregnancy Category: Always consult your physician before use.
Storage: Store at room temperature, away from direct light and heat.
Reviews
There are no reviews yet.