Avsar Plus 10/160/25 Tab (Amlodipine+Hydrochlorothiazide+Valsartan) Tab 28’s

The combination of amlodipine, hydrochlorothiazide, and valsartan in this tablet has a synergistic effect on lowering blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Hydrochlorothiazide, a thiazide diuretic, increases urinary excretion of sodium and water, which decreases blood volume and reduces blood pressure. Valsartan, an angiotensin II receptor blocker (ARB), blocks the binding of angiotensin II to its receptors, resulting in vasodilation, reduced vasopressor activity, and decreased aldosterone secretion, ultimately leading to lower blood pressure. Together, these mechanisms effectively reduce blood pressure by targeting different pathways involved in vascular tone and fluid balance.

Amlodipine 10mg, Hydrochlorothiazide 25mg, Valsartan 160mg

Calcium channel blocker, Diuretic, Angiotensin II antagonist.

Tablet

The following are the uses of Amlodipine 10mg, Hydrochlorothiazide 25mg, valsartan 160mg Tablet:

• Used for treating high blood pressure (hypertension) to lower the risk of heart attack and stroke.
• Used for relaxing blood vessels and improving blood flow.
• Used to reduce excess fluid and salt in the body.
• Used to block the effects of a specific natural substance that tightens blood vessels.
• Used for improving heart health and reducing strain on the heart.
• Used for managing hypertension when other medications have not been effective.
• Used to improve overall cardiovascular function and health.
• Used to prevent the progression of hypertension-related complications.

To be taken as per doctor’s prescription

In the case of an overdose of Amlodipine 10mg, Hydrochlorothiazide 25mg, and valsartan 160mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and an increased heart rate. Other potential effects include hypotension, bradycardia, and even loss of consciousness. Prompt medical attention is necessary to manage these symptoms effectively. It is crucial to contact emergency services or seek medical advice immediately if an overdose is suspected.

In the case of a missed dose of Amlodipine 10mg, take it as soon as you remember, but if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. For Hydrochlorothiazide 25mg, if you miss a dose, take it as soon as possible, but skip it if it’s close to the time for your next dose. Valsartan 160mg can be taken immediately if you forget to take it, but if it’s almost time for your next dose, it’s best to skip the missed one to maintain a consistent medication routine. Consult your healthcare provider if you frequently miss doses for guidance on managing your medication schedule.

To take the Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Here are the conditions or situations when Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet should not be used:

• Should not be used in individuals with a known allergy to any of the components, including Amlodipine, Hydrochlorothiazide, or Valsartan.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Should be avoided in patients with a history of angioedema (swelling of the face, lips, tongue, or throat) after taking Amlodipine or other similar medications.
• Not suitable for individuals with low blood pressure (hypotension) or those who have recently experienced a heart attack or unstable angina.
• Should not be used during pregnancy or while breastfeeding.
• Contraindicated in patients with severe hyperkalemia (high potassium levels in the blood).
• Not recommended for individuals with narrowing of the aortic or mitral valve in the heart.
• Avoid using this medication in patients with a history of sulfonamide allergy, as Hydrochlorothiazide is a sulfonamide-derived medication.
• Should not be used in patients with gout or diabetes, as Hydrochlorothiazide may increase uric acid levels and affect blood sugar control.

The side effects of Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea or stomach pain
• Increased urination
• Skin rash or itching
• Swelling in the legs or ankles
• Low blood pressure (hypotension)

Following are the precautions and warnings for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet:

• This medication should not be used in patients with known allergies to any of its components, including amlodipine, hydrochlorothiazide, or valsartan.
• Patients with renal impairment or a history of kidney problems should exercise caution and have regular kidney function monitoring while on this medication.
• It may cause hypotension (low blood pressure); patients should be cautious when standing up to prevent dizziness or fainting.
• Regular monitoring of blood pressure, kidney function, and electrolyte levels is necessary during treatment.
• Avoid potassium supplements or potassium-rich foods without medical advice, as it may affect electrolyte balance.
• Not recommended for use during pregnancy or breastfeeding; consult your doctor for alternative options.
• Inform your doctor about all medications you are taking, especially diuretics, NSAIDs, or other blood pressure medications, to prevent potential drug interactions.

Following are the drug interactions for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet:

• Amlodipine may increase the blood pressure-lowering effect of Hydrochlorothiazide and Valsartan, potentially causing excessive hypotension.
• Lithium levels may be increased by Hydrochlorothiazide, requiring monitoring and possible dose adjustment.
• Valsartan may have reduced effectiveness when combined with NSAIDs, as these drugs may decrease its antihypertensive and renal protective effects.
• When taken with nonsteroidal anti-inflammatory drugs (NSAIDs), Amlodipine may have its blood pressure-lowering effect diminished.
• Hydrochlorothiazide can increase blood sugar levels, which may affect the efficacy of antidiabetic medications.
• The combination of Amlodipine and Valsartan with other blood pressure medications may result in additive hypotensive effects.
• Digoxin levels may be increased by Hydrochlorothiazide, requiring close monitoring of digoxin concentrations.
• Valsartan may increase the risk of hyperkalemia when used with potassium-sparing diuretics or potassium supplements.

Following are the food interactions for Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Amlodipine in the blood, potentially leading to an increased risk of side effects.
• Alcohol may lower your blood pressure further and increase the side effects of Hydrochlorothiazide, causing increased dizziness or lightheadedness.
• Avoid excessive salt or potassium-rich foods while taking Valsartan, as it can alter the balance of these electrolytes in your body.
• Dairy products like milk and yogurt may decrease the absorption of Hydrochlorothiazide; consider separating these by a few hours.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation to maintain a balanced potassium level.
• Licorice can decrease the effectiveness of Valsartan and should be avoided.
• Avoid excessive alcohol consumption as it may interact with all three medications, leading to increased side effects and potential health risks.
• Always stay hydrated by drinking enough water to maintain proper kidney function.

Amlodipine 10mg, Hydrochlorothiazide 25mg, and Valsartan 160mg tablets should be stored in a cool, dry place, preferably at room temperature (68°F to 77°F). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It’s crucial to avoid exposing the medication to excessive heat or cold, so steer clear of storing it in the bathroom or kitchen. When it’s time to discard any unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste disposal company for safe disposal options. Always keep medications out of children’s reach to prevent accidental consumption.