Aromek Tablets 2.5Mg (1 Bottle = 10 Tablets)

Requires Prescription: Yes

Generics: Letrozole

Used For: Cancer treatment

How It Works: Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme, blocking the conversion of androgens to estrogens. It is effective in reducing estrogen-dependent tumors and has a similar effect to ovariectomy but without increasing serum FSH.

Usage and Safety:

Dosage: Follow prescribed dosage of letrozole.

Side Effects:

Common: Abdominal pain, alopecia, anorexia, appetite increase, arthralgia, bone fracture, constipation, depression, diarrhea, dizziness, dry skin, dyspepsia, fatigue, headache, hot flushes, hypercholesterolemia, hypertension, increased sweating, musculoskeletal pain, nausea, osteoporosis, peripheral edema, rash, vaginal bleeding, vomiting, weight changes.

Uncommon: Anxiety, arthritis, blurred vision, breast pain, cardiac events, cataract, cerebrovascular events, cough, dysaesthesia, dyspnea, eye irritation, general edema, insomnia, leucopenia, memory impairment, mucosal dryness, palpitation, pruritus, pyrexia, stomatitis, tachycardia, taste disturbance, thrombophlebitis, tumor pain, urinary frequency, urinary tract infection, urticaria, vaginal discharge.

Rare: Arterial thrombosis, pulmonary embolism.

Frequency Not Known: Hepatitis, toxic epidermal necrolysis.

Drug Interactions: Tamoxifen, cimetidine, warfarin.

Indication:

• First-line treatment for postmenopausal women with hormone-dependent advanced breast cancer.
• Adjuvant treatment for estrogen receptor-positive invasive early breast cancer in postmenopausal women.
• Advanced breast cancer in postmenopausal women where other antiestrogen therapies have failed.
• Extended adjuvant treatment for hormone-dependent invasive breast cancer in postmenopausal women who have received standard adjuvant tamoxifen therapy for 5 years.
• Neoadjuvant treatment for localized hormone receptor-positive, HER2-negative breast cancer in postmenopausal women where chemotherapy is unsuitable and surgery is not yet indicated.

When Not to Use: Contraindicated in cases of hypersensitivity to letrozole or any excipients, premenopausal women, pregnant or breastfeeding women.

Precautions: Caution advised when driving or operating machinery due to potential fatigue, dizziness, or somnolence.

Warnings:

• Use of letrozole may decrease bone mineral density (BMD). Assess bone density before starting treatment, especially in women with a history of osteoporosis or fractures.
• Monitor serum cholesterol levels.
• Dose reduction recommended for patients with cirrhosis or severe hepatic impairment due to increased exposure to letrozole.

Additional Information:

Pregnancy Category: Consult your physician before use.

Storage: Store at room temperature, away from direct light and heat.