Arbi-D 300/12.5mg (Irbesartan+Hydrochlorothiazide) Tab 10’s

Hydrochlorothiazide and Irbesartan are combined in this tablet to treat hypertension. Hydrochlorothiazide is a diuretic that increases urination, reducing fluid retention and lowering blood pressure by inhibiting the reabsorption of sodium and chloride ions in the distal tubule of the kidneys. This action promotes the excretion of water and sodium, leading to a decrease in blood volume and, consequently, a reduction in blood pressure. Irbesartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II receptors, preventing the hormone angiotensin II from binding to these receptors in blood vessels and the heart. Angiotensin II is a potent vasoconstrictor, so by blocking its receptors, Irbesartan causes blood vessels to relax and dilate, thereby lowering blood pressure. This dual mechanism of action, combining diuretic and angiotensin II receptor blockade, provides a synergistic effect in reducing blood pressure and managing hypertension.

Hydrochlorothiazide, Irbesartan

Angiotensin II Receptor Blocker

Tablet

The following are the uses of Hydrochlorothiazide, Irbesartan Tablet:

• Used for controlling high blood pressure (hypertension).
• Used to lower blood pressure and reduce the risk of stroke, heart attack, and kidney problems.
• Used to treat hypertension in patients who may have difficulty tolerating other blood pressure medications.
• Used to improve blood flow and reduce strain on the heart and arteries.
• Used to manage fluid retention and edema associated with hypertension.
• Used to help prevent the progression of kidney disease in diabetic patients with high blood pressure.
• Used to reduce the workload on the heart and improve overall cardiovascular health.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Hypertension- Take 1 tablet of Irbesartan 300mg and Hydrochlorothiazide 12.5mg once daily.
• Heart failure- Take 1 tablet of Irbesartan 300mg once daily. Your doctor may prescribe a higher dose of 300mg twice daily if you have severe heart failure.
• Kidney disease- The usual dose ranges from 150mg to 300mg once daily.
• Diabetic nephropathy- Take 300mg once daily.

In the case of an overdose of Hydrochlorothiazide and Irbesartan Tablets, individuals may experience symptoms such as dizziness, lightheadedness, and hypotension. It is important to seek medical advice promptly, as severe cases can lead to more serious complications. Treatment for overdose may involve monitoring vital signs, providing supportive care, and potentially administering specific medications to counteract the effects of the overdose. Timely intervention can help manage the situation effectively.

In the case of a missed dose of Hydrochlorothiazide, Irbesartan Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It is important to maintain a consistent medication routine, but if you miss a dose, consult your healthcare provider for advice on how to adjust your dosing schedule to ensure you receive the full benefit of the medication.

To take Hydrochlorothiazide, Irbesartan Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once daily, to effectively manage your blood pressure.

Following are the conditions or situations when Hydrochlorothiazide, Irbesartan Tablet should not be used:

• Should not be used in patients with a known allergy to either Hydrochlorothiazide or Irbesartan, or any other sulfonamide-derived drugs.
• Contraindicated in individuals with severe kidney disease or those who are unable to produce urine.
• Not suitable for patients with severe liver disease or biliary obstruction.
• Should be avoided during pregnancy, especially in the second and third trimesters.
• Not recommended for individuals with a history of angioedema or swelling of the face, lips, tongue, or throat.
• Contraindicated in patients with severe hyperkalemia (high potassium levels in the blood).
• Should not be used in patients with diabetic nephropathy (kidney disease due to diabetes).
• Avoid in patients with severe aortic stenosis (narrowing of the aortic valve in the heart).
• Not suitable for individuals with systemic lupus erythematosus (SLE).

The side effects of Hydrochlorothiazide, Irbesartan Tablet may include:

• Dizziness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• Muscle cramps or spasms
• Increased sensitivity to sunlight
• Skin rash or itching
• Low blood pressure (hypotension)

Following are the precautions and warnings:

• Hydrochlorothiazide, Irbesartan Tablet should not be used in patients with a known allergy or sensitivity to either hydrochlorothiazide or irbesartan or any other components of the tablet.
• This medication may cause an imbalance in electrolytes, particularly in patients with kidney or liver disease, so regular monitoring of potassium, sodium, and other electrolyte levels is necessary.
• Caution is advised for patients with a history of kidney problems as the medication’s effects may be altered, and dosage adjustments might be required.
• Hydrochlorothiazide may cause an increased sensitivity to the sun, so patients should limit sun exposure and use protective measures when outdoors.
• Patients with a history of angioedema should exercise caution as irbesartan can cause swelling of the face, lips, throat, or tongue.
• This medication may not be suitable for pregnant or breastfeeding women, so they should consult their healthcare provider before use.
• It is important to inform your doctor if you have any heart or blood vessel conditions, diabetes, or a history of kidney stones before starting this medication.
• Patients should not take potassium supplements or potassium-containing salt substitutes without medical advice while on this medication.

Following are the drug interactions for Hydrochlorothiazide, Irbesartan Tablet:

• Lithium levels can be increased by thiazide diuretics like hydrochlorothiazide, potentially leading to lithium toxicity. Close monitoring of lithium levels is advised.
• The blood pressure-lowering effect of Irbesartan may be reduced by NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) like ibuprofen or naproxen.
• Hydrochlorothiazide can decrease the elimination of calcium channel blockers like amlodipine, potentially leading to increased side effects.
• Potassium-depleting effects can be enhanced when combined with corticosteroids or other drugs that deplete potassium. Monitoring potassium levels is recommended.
• The antihypertensive effect of Irbesartan may be reduced by the use of sympathomimetic agents like epinephrine or norepinephrine.
• Hydrochlorothiazide may increase blood sugar levels, which can be a concern when used with antidiabetic medications, requiring close monitoring.
• Drugs affecting renal function, such as cyclosporine, may alter the effects of Hydrochlorothiazide.

Following are the food interactions for Hydrochlorothiazide, Irbesartan Tablet:

• Avoid excessive salt intake (sodium) in your diet. This medication may make your body lose the ability to regulate sodium and potassium properly.
• Potassium-rich foods like bananas, oranges, and green leafy vegetables should be included in your diet as this medication can cause potassium loss.
• Limit alcohol consumption as it may increase the risk of dizziness and lightheadedness, especially when standing from a sitting or lying position.
• Avoid grapefruit and grapefruit juice as they can interfere with the medication’s metabolism, leading to increased drug levels in the body.
• Avoid or limit high-fat meals as they can affect the absorption and effectiveness of Irbesartan.
• Avoid or limit licorice consumption, especially if you have heart issues, as it can interfere with the medication’s effects on blood pressure and potassium levels.
• Stay hydrated and drink plenty of fluids, especially in hot weather or during exercise, to prevent dehydration due to increased urination.
• Consult your doctor or pharmacist about any specific dietary restrictions or recommendations based on your overall health condition.

Hydrochlorothiazide, Irbesartan Tablets should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from light and moisture by keeping them in their original container with the lid tightly sealed. It is crucial not to store them in the bathroom or kitchen, as these areas may have high humidity and temperature fluctuations. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them properly. For safe disposal, do not throw the medication in the trash or flush it down the toilet; consult a pharmacist or local waste disposal company for guidance on medication disposal programs. Keep the medication out of children’s reach to prevent accidental consumption.