Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in mediating pain, inflammation, and fever. By blocking the action of COX enzymes, naproxen sodium reduces the production of prostaglandins, thereby providing pain relief and reducing inflammation. It achieves this by competitively and reversibly binding to the active site of the COX enzymes, preventing the conversion of arachidonic acid into prostaglandin H2, the common precursor for various prostaglandins and thromboxanes. This inhibition of prostaglandin synthesis underlies naproxen’s therapeutic effects, making it effective in managing pain, inflammation, and fever associated with various conditions.


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