Advantec Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Candesartan Cilexetil , Hydrochlorothiazide
Used For
Hypertension
How it works
Candesartan Cilexetil: Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis.Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because candesartan does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Hydrochlorothiazide: Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics. The mechanism of the antihypertensive effect of thiazides is unknown.
Advantec Tablets Usage And Safety
Dosage
Candesartan Cilexetil , Hydrochlorothiazide
Side Effects
Common : Back pain, dizziness, flu-like symptoms, headache, upper respiratory infection.Less Common : Abdominal pain, change in amount of urine, increased sweating, unusual thirst, fainting, gastrointestinal disorders, mood swings.Rare : Persistent sore throat, cough, fever, unusual fatigue, unusual bleeding or bruising, pale skin and eyes, dark urine, chest pain, irregular heartbeats, joint pain.
Drug Interactions
Candesartan Cilexetil : Lithium , Hydrochlorothiazide : Thiazide diuretics , Alcohol, barbiturates or narcotics , Anti-diabetic (Oral agents and insulin) , Chloestyramine and colestipol resins , Corticosteroids, ACTH , Pressor amines (norepinephrine) , Skeletal muscle relaxant (tubocurarine) , Lithium , NSAIDs
Indication
Candesartan Cilexetil + Hydrochlorothiazide is indicated for the treatment of hypertension. The fixed dose combination is not indicated for initial therapy.
When not to Use
Candesartan Cilexetil + Hydrochlorothiazide is contraindicated:- In patients who are hypersensitive to this drug or any component of this product.- In patients with anuria or hypersensitivity to other sulfonamide-derived drugs, due to hydrochlorothiazide component in the preparation.- In concomitant use with other antihypertensive drugs like, dofetilide.- In patients with more severe renal impairment.
Advantec Tablets Precautions
Precaution
In patients with an activated renin-angiotensin system, such as volume and/or salt-depleted patients (e.g., those being treated with diuretics), symptomatic hypotension may occur. These conditions should be corrected prior to administration , or the treatment should start under close medical supervision.
Advantec Tablets Warnings
Warning 1
As a consequence of inhibiting the renin angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals treated with candesartan.
Warning 2
Thiazide diuretics should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Warning 3
Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
Advantec Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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