Velosef 125 mg (Cefradine) Syp 90 ml

Cephradine 125mg Syrup/Suspension is a broad-spectrum antibiotic that belongs to the class of cephalosporins. It works by inhibiting the synthesis of the bacterial cell wall, which is essential for the bacteria’s structural integrity. Cephradine binds to specific penicillin-binding proteins (PBPs) located on the bacterial cell membrane, disrupting the final stages of cell wall formation. This leads to the weakening of the cell wall, causing the bacteria to lyse (break open) and ultimately die. Cephradine is effective against a variety of gram-positive and gram-negative bacteria, making it useful in treating various bacterial infections.

Cephradine 125mg

Cephalosporins

Syrup/Suspension

The following are the uses of Cephradine 125mg Syrup/Suspension:

• Treatment of respiratory tract infections such as pneumonia and bronchitis caused by susceptible bacteria.
• Management of urinary tract infections (UTIs), including cystitis and pyelonephritis.
• Treatment of skin and soft tissue infections, including cellulitis and abscesses.
• Management of ear infections such as otitis media.
• Treatment of dental infections.
• Management of upper respiratory tract infections like pharyngitis and tonsillitis.
• Treatment of bone and joint infections caused by sensitive bacteria.

Following are the doses of Cephradine 125mg Syrup/Suspension:

• The usual dose for children (based on weight and age) is 12.5 to 25 mg per kilogram of body weight per day, divided into two to four doses.
• For adults, the typical dose is 250 mg to 500 mg every 6 hours, depending on the severity of the infection.
• In cases of more severe infections, the dose may be increased as per the healthcare provider’s instructions.
• The exact dosage should be based on the specific infection being treated and the advice of the healthcare provider.

In case of an overdose of Cephradine 125mg Syrup/Suspension, immediate medical attention should be sought. An overdose of Cephradine may lead to symptoms such as nausea, vomiting, or diarrhea. If excessive medication is accidentally ingested, it is recommended to contact your healthcare provider or a poison control center immediately. Do not attempt to induce vomiting or take any other actions without consulting a healthcare provider. If severe symptoms like confusion, dizziness, or persistent gastrointestinal discomfort occur, seek medical attention right away. Always follow the prescribed dosage and usage instructions to avoid overdose.

If you miss a dose of Cephradine 125mg Syrup/Suspension, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for the missed dose, as this could increase the risk of side effects. Always follow the dosing instructions provided by your healthcare provider, and consult them if you’re unsure about how to proceed after missing a dose.

To use Cephradine 125mg Syrup/Suspension, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken orally, with or without food, as directed by your doctor. Shake the bottle well before measuring the dose to ensure the medication is evenly distributed. Use the provided measuring device (e.g., a syringe or spoon) to ensure accurate dosing.

Following are the situations when Cephradine 125mg Syrup/Suspension should not be used:

• Should not be used in individuals with a known allergy to Cephradine or other cephalosporin antibiotics.
• Contraindicated in patients who have a history of severe allergic reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
• Should not be used in individuals with a history of severe gastrointestinal issues such as colitis, especially when associated with antibiotic use.

The side effects of Cephradine 125mg Syrup/Suspension may include:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Rash
• Allergic reactions such as hives or swelling
• Headache
• Dizziness
• Changes in urine output or color (in rare cases)
• Joint pain (in rare cases)

Following are the precautions and warnings for Cephradine 125mg Syrup/Suspension:

• Should not be used in individuals with a known allergy to Cephradine or other cephalosporins.
• Caution is advised in patients with a history of kidney disease, as Cephradine is eliminated through the kidneys and impaired kidney function may increase the risk of drug accumulation and side effects.
• Cephradine should be used with caution in patients with a history of gastrointestinal disorders, as it may cause or worsen gastrointestinal symptoms such as nausea, vomiting, or diarrhea.
• Prolonged use of Cephradine may lead to overgrowth of non-susceptible organisms, such as fungi or other bacteria.
• Discontinue Cephradine if severe allergic reactions, such as anaphylaxis or skin rashes, occur.
• Caution is recommended when using Cephradine with other medications that may affect kidney function, as this may increase the risk of nephrotoxicity.

Following are the drug interactions for Cephradine 125mg Syrup/Suspension:

• Concomitant use with probenecid may increase Cephradine levels in the blood, leading to a higher risk of side effects.
• Antacids containing aluminum or magnesium may reduce the absorption of Cephradine, so it is advised to separate the administration of antacids and Cephradine by at least 2 hours.
• The use of Cephradine with other antibiotics, especially those that affect renal function, should be monitored closely to avoid kidney damage or reduced effectiveness of either drug.
• Cephradine should be used cautiously with blood-thinning medications (anticoagulants) as it may increase the risk of bleeding.

Following are the food interactions for Cephradine 125mg Syrup/Suspension:

• Taking Cephradine with food may reduce its absorption, but it does not significantly affect its effectiveness.
• It is generally recommended to take Cephradine on an empty stomach for optimal absorption, typically 1 hour before or 2 hours after meals.
• Avoid alcohol consumption while using Cephradine, as it may increase the risk of certain side effects such as stomach upset or dizziness.
• Dairy products do not have a significant impact on Cephradine, but it is advised to follow your healthcare provider’s guidance regarding food intake with the medication.

Cephradine 125mg Syrup/Suspension should be stored at room temperature, away from heat, moisture, and direct sunlight. Ensure that the syrup is kept in its original container with the cap tightly closed to prevent contamination. Do not refrigerate or freeze the medication, as it may alter its effectiveness. Always keep it out of reach of children to avoid accidental ingestion. Dispose of any unused or expired syrup according to the instructions provided by your healthcare provider or local disposal guidelines. Do not flush medications down the toilet or pour them into drains unless directed to do so. Proper disposal helps protect the environment and reduces the risk of misuse.

Following are the quick tips for Cephradine 125mg Syrup/Suspension:

• Take Cephradine syrup as prescribed by your healthcare provider for optimal results.
• Shake the bottle well before each use to ensure the correct dosage.
• Use a proper measuring device (such as a dose-measuring spoon or cup) to ensure accurate dosing.
• Complete the full prescribed course of treatment, even if you feel better before finishing the medication, to prevent reinfection or resistance.
• Store the syrup in a cool, dry place, away from direct sunlight and moisture.
• If you miss a dose, take it as soon as you remember, but if it’s close to the time for your next dose, skip the missed dose—do not double the dose.
• If you experience any side effects like rash, diarrhea, or signs of an allergic reaction, contact your healthcare provider immediately.

Cephradine 125mg Syrup/Suspension does not typically require routine lab screening or monitoring. However, in certain cases where there are concerns related to kidney function, infection management, or underlying conditions, the following may be considered:

• Regular monitoring of kidney function in patients with pre-existing renal conditions, as Cephradine is primarily excreted through the kidneys.
• Complete blood counts (CBC) may be conducted to monitor for potential adverse reactions such as leukopenia or eosinophilia during prolonged therapy.
• Liver function tests may be considered in patients who develop symptoms suggesting hepatic impairment.
• If you experience any significant side effects, such as persistent diarrhea, allergic reactions, or signs of superinfection, consult your healthcare provider for further evaluation.
• Patients with a history of gastrointestinal disease, renal dysfunction, or hypersensitivity to cephalosporins should be closely monitored.