Velon-M 50/1000 mg (Vildagliptin+Metformin) Tab 28’s

Metformin primarily works by reducing glucose production in the liver. It inhibits gluconeogenesis, the process by which the liver makes new glucose, and decreases the absorption of glucose in the intestines. Metformin also enhances insulin sensitivity, allowing the body’s own insulin to work more effectively in facilitating glucose uptake by cells. On the other hand, Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the levels of incretin hormones, such as GLP-1 (glucagon-like peptide-1), by inhibiting their breakdown. This leads to enhanced insulin secretion in response to meals and reduced glucagon secretion, resulting in lower blood glucose levels. The combined effect of Metformin and Vildagliptin helps improve glycemic control in patients with type 2 diabetes.

Biguanide, DPP-4 inhibitor.

Tablet

The following are the uses of Metformin 1000mg, Vildagliptin 50mg Tablet:

• Used for treating type 2 diabetes by controlling blood sugar levels
• Used to improve insulin sensitivity and reduce insulin resistance
• Used to lower glucose production in the liver
• Used to enhance the body’s response to its naturally produced insulin
• Used to reduce the risk of diabetes-related complications
• Used to manage weight and improve overall metabolic health
• Used to regulate appetite and promote weight loss
• Used to support long-term blood sugar control and diabetes management

To be determined by the doctor

In the case of an overdose of Metformin 1000mg and Vildagliptin 50mg Tablet, symptoms may include lactic acidosis, hypoglycemia, and gastrointestinal distress. Lactic acidosis can lead to rapid breathing, abdominal pain, and unusual muscle pain. Hypoglycemia may cause dizziness, confusion, and seizures. Gastrointestinal symptoms such as nausea, vomiting, and diarrhea are also common. It is important to seek medical advice if you suspect an overdose, as prompt treatment can prevent serious complications.

In the case of a missed dose of Metformin 1000mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In this situation, it is best to skip the missed dose and continue with your regular dosing schedule. For Vildagliptin 50mg, if you miss a dose, take it as soon as you remember, but if it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing. It’s important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice.

To take the Metformin 1000mg and Vildagliptin 50mg Tablet, swallow the tablet whole with a full glass of water, preferably during or after a meal, exactly as prescribed by your doctor, typically twice a day.

Following are the conditions/situations when Metformin 1000mg and Vildagliptin 50mg Tablet should not be taken:

• Not recommended for individuals with a known allergy to Metformin, Vildagliptin, or any of the tablet’s components.
• Should not be used in patients with severe kidney disease or kidney failure.
• Contraindicated in individuals with diabetic ketoacidosis.
• Not suitable for patients with severe liver disease or liver failure.
• Should be avoided in patients with a history of pancreatitis or current pancreatitis.
• Not recommended for individuals with a history of alcohol abuse or heavy alcohol consumption.
• Discontinue use before any radiologic studies involving intravascular administration of iodinated contrast materials.
• Do not take if you have a severe infection or are experiencing a traumatic event, as it may increase the risk of lactic acidosis.

The side effects of Metformin 1000mg, Vildagliptin 50mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or loose stools
• Metallic taste in the mouth
• Loss of appetite
• Headache
• Weakness or fatigue
• Skin rash or itching

Following are the precautions and warnings for Metformin 1000mg, Vildagliptin 50mg Tablet:

• This medication is not recommended for individuals with a known allergy to Metformin or Vildagliptin.
• Patients with kidney or liver disease should exercise caution and consult a doctor, as dosage adjustments may be necessary.
• It is important to maintain a balanced diet and monitor blood glucose levels regularly while taking this medication.
• Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis.
• If you experience any symptoms of lactic acidosis such as weakness, muscle pain, or stomach discomfort, seek medical attention immediately.
• Patients should be aware of the risk of hypoglycemia and carry a source of glucose like candy or juice to treat low blood sugar.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.
• Do not stop taking the medication without consulting your healthcare provider, as it may affect blood sugar control.

Following are the drug interactions for Metformin 1000mg, Vildagliptin 50mg Tablet:

• Alcohol consumption may increase the risk of lactic acidosis with metformin.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the glucose-lowering effect of vildagliptin.
• Concomitant use with sulfonylureas or insulin may increase the risk of hypoglycemia.
• Metformin may interact with contrast media used in medical imaging, increasing the risk of kidney-related issues.
• Vildagliptin may increase the concentration of digoxin, a heart medication.
• Drugs that affect kidney function may impact the elimination of both metformin and vildagliptin.
• Caution is advised when combining with other antidiabetic medications, as dose adjustments may be required.

Following are the food interactions for Metformin 1000mg and Vildagliptin 50mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of lactic acidosis, especially with Metformin.
• Avoid excessive consumption of foods high in glucose or sucrose, as Vildagliptin may enhance their absorption.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Vildagliptin, potentially altering its effectiveness.
• Dairy products, such as milk and yogurt, may decrease the absorption of Vildagliptin. Consider separating their intake by a few hours.
• High-fat meals might slightly delay the absorption of Vildagliptin, but it doesn’t significantly impact its effectiveness.
• No known significant food interactions with Metformin, but maintaining a balanced diet is essential for managing blood sugar levels.
• Follow a consistent carbohydrate intake pattern to optimize the effectiveness of both medications.
• Always consult your healthcare provider for personalized dietary advice and any specific food restrictions related to your medication regimen.

Metformin 1000mg and Vildagliptin 50mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity. Avoid placing the tablets in humid areas like bathrooms or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Always check the expiration date before use, and if the medication is no longer needed or has expired, it should be disposed of responsibly. Do not dispose of it via sinks or toilets; instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods, ensuring that the medication is kept secure and out of the reach of children.

No

Following are the quick tips for Metformin 1000mg and Vildagliptin 50mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablets whole with a full glass of water; do not crush or chew.
• Take your dose with a meal or just after to minimize stomach-related side effects.
• Maintain a consistent medication schedule by taking your dose at the same time each day.
• Do not skip doses; if you miss a dose, take it as soon as you remember, unless it’s close to your next dose.
• Inform your doctor about all other medications you’re taking to prevent potential drug interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.