Co-Renitec 10/25 mg (Enalapril+Hydrochlorothiazide) Tab 20’s

Introduction

How To Use

• Take this medicine with or without food.
• Usual doses are of one or two tablets per day.
• Please consult your doctor for dose adjustments and duration of this medicine.

Expert Advice

Take this medicine 1 hour before or 2 hours after meal. 

Don’t crush/chew tablets.

Change position slowly.

Take ample amount of liquids to prevent dehydration.

Primary Uses

Hypertension

Indications

Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which regulates blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin-aldosterone system to lower blood pressure. Being a prodrug, enalapril is rapidly biotransformed into its active metabolite, enalaprilat, which is responsible for the pharmacological actions of enalapril. The active metabolite of enalapril competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the renin-angiotensin-aldosterone system that promotes vasoconstriction and renal reabsorption of sodium ions in the kidneys. Ultimately, enalaprilat works to reduce blood pressure and blood fluid volume. This medicine is used in congestive heart faliure and for all stages of hypertension (high blood pressure) where standard therapy is uneffective.

Side Effects

The use of this medicine is associated with side effects such as neutropenia (low levels of white blood cells), hypotension (low blood pressure), rash or loss of taste, chest pain, angina, Gi upset, blurred vision, dyspnoea (shortness of breath). Withdraw if jaundice occurs. 

Contraindications

This medicine is not recommended to be used in patients with aortic stenosis (narrowing of aortic valve) and kidney impairment, Cardiogenic shock, angioedema (swelling in deep layers of skin).

FAQS

Can I take this medicine with brufen and asprin?

Kindly consult your doctor before taking these medicines together. They may enhance the effect of this drug.

Can this medicine cause changes in weight?

Weight changes are a possible side effect of taking this medicine. Kindly consult your doctor if this occurs

Will this drug cause dizziness or headaches?

Headaches and dizziness are common and possible side effects of this medicine. To prevent dizziness, try to avoid getting up abruptly when you are lying down, or any other sudden movements. Avoid activities that require alertness such as driving etc.

Can I stop taking this medicine once my blood pressure is normal?

This medicine should not be stopped unless your doctor recommends it, and it should not be stopped abruptly. Kindly follow the instructions of your physician regarding how and when to stop taking this drug.

Does enalapril make you urinate more?

Yes, this medicine might make you urinate more often.

What is hydrochlorothiazide and how does it work?

It is a diuretic which helps to lower the blood pressure by removing extra water and certain electrolytes from your body. It also relaxes the blood vessels and improves blood flow. It is also used to treat excessive accumulation of fluid in the body.

Is this medicine a statin?

No. This medicine is a derivative of chlorothiazide.

Is this drug bad for my kidneys?

No this drug is safe to use in kidneys. Consult your doctor if you have any kidney disease, he will alter the dosage of this medicine accordingly.

When is the right time to take this medicine?

It advised to take this medicine with breakfast in the morning to avoid excessive urination at night.

Can I use this medicine during pregnancy?

Yes, you may use this drug in pregnancy but with your doctor’s advice.

Is this medicine safe to use in breast-feeding?

No, this medicine is not recommended for use during lactation.

I have diabetes, can I use this medication?

This medicine increases blood glucose levels in patients with diabetes. It is therefore advised to use this drug cautiously and upon doctor’s advice only. Regular glucose monitoring is necessary with the use of this drug.

Can this medicine be used if I have a liver failure?

This medicine should be used with caution in patients suffering from any liver disease. If you experience any symptoms of jaundice please consult your doctor.