Stomacol Tablets 10Mg (1 Strip = 10 Tablets)

Requires Prescription: Yes

Generics: Domeperidone Maleate

Used For: Nausea & Vomiting

How It Works:

Stomacol Tablets have antiemetic effects due to a combination of peripheral (gastrokinetic) actions and antagonism of dopamine receptors in the chemoreceptor trigger zone, which is located outside the blood-brain barrier in the area postrema.

Stomacol Tablets Usage and Safety:

Dosage:

Domeperidone Maleate

Side Effects:

Depression (2.5%)

Anxiety (1.6%)

Decreased Libido / Loss of Libido

Headache (5.6%)

Somnolence (2.5%)

Akathisia (1%)

Diarrhea (5.2%)

Rash (2.8%)

Pruritus (1.7%)

Breast Enlargement / Gynaecomastia (5.3%)

Breast Tenderness (4.4%)

Galactorrhea (3.3%)

Amenorrhea (2.9%)

Breast Pain (2.3%)

Irregular Menstruation (2.0%)

Lactation Disorder (1.6%)

Drug Interactions:

Domeperidone may interact with:

CYP3A4 inhibitors (e.g., indinavir)

Antiarrhythmics (e.g., disopyramide, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol)

Certain antipsychotics (e.g., haloperidol, pimozide, sertindole)

Certain antidepressants (e.g., citalopram, escitalopram)

Certain antibiotics (e.g., levofloxacin, moxifloxacin)

Certain antifungal agents (e.g., pentamidine)

Certain antimalarial agents (e.g., halofantrine)

Certain gastrointestinal drugs (e.g., dolasetron)

Certain cancer drugs (e.g., toremifene, vandetanib)

Other drugs (e.g., bepridil, methadone)

Indication:

Used for the treatment of nausea and vomiting.

When Not to Use:

Domeperidone is contraindicated in:

Patients with moderate to severe hepatic impairment

Patients with existing prolongation of cardiac conduction intervals (particularly QTc) or significant electrolyte disturbances

Patients with underlying cardiac conditions such as congestive heart failure

Stomacol Tablets Precautions:

Precaution:

Epidemiological studies suggest that domperidone may be associated with an increased risk of serious ventricular arrhythmias or sudden cardiac death.

Stomacol Tablets Warnings:

Warning 1:

Patients older than 60 years should consult their physician before taking domeperidone maleate.

Warning 2:

Due to the increased risk of ventricular arrhythmia, domeperidone maleate is not recommended for patients with existing cardiac conduction interval prolongation, particularly QTc, or significant electrolyte disturbances.

Warning 3:

Treatment should be discontinued if signs or symptoms of cardiac arrhythmia occur, and patients should promptly consult their physician.

Additional Information:

Pregnancy Category:

Always consult your physician before using any medicine.

Storage:

Store at room temperature, away from direct light and heat.